| Literature DB >> 18601923 |
Pasquale Gallina1, Marco Paganini, Letizia Lombardini, Riccardo Saccardi, Mirca Marini, Maria Teresa De Cristofaro, Pamela Pinzani, Francesca Salvianti, Clara Crescioli, Andrea Di Rita, Sandra Bucciantini, Claudia Mechi, Erica Sarchielli, Marco Moretti, Silvia Piacentini, Gaetano Gritti, Alberto Bosi, Sandro Sorbi, Giovanni Orlandini, Gabriella B Vannelli, Nicola Di Lorenzo.
Abstract
Replacement of damaged neuronal population by fetal tissue transplantation represents a potential treatment for neurodegenerative diseases. Consistent success has been achieved with fetal striatal transplantation in Huntington's disease animal models and patients. We report the neo-generation of metabolically active tissue with striatum-like imaging features after transplantation of striatal primordia in a patient with Huntington's disease. This study represents the first "in vivo" demonstration that a human striatal anlagen, transplanted into the adult human brain, is able to progress in its development and to generate a new anatomical structure in the host, without evidence of neoplasia or teratoma.Entities:
Mesh：
Year: 2008 PMID： 18601923 DOI： 10.1016/j.expneurol.2008.06.003
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330