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Literature DB >> 18601695

Kisspeptin and GPR54: discovery of a novel pathway in reproduction.

Abstract

In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18601695 PMCID： PMC2869294 DOI： 10.1111/j.1365-2826.2008.01731.x

Source DB: PubMed Journal: J Neuroendocrinol ISSN： 0953-8194 Impact factor: 3.627

31 in total

1. Central and peripheral administration of kisspeptin-10 stimulates the hypothalamic-pituitary-gonadal axis.

Authors: E L Thompson; M Patterson; K G Murphy; K L Smith; W S Dhillo; J F Todd; M A Ghatei; S R Bloom
Journal: J Neuroendocrinol Date: 2004-10 Impact factor: 3.627

2. A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules.

Authors: B Franco; S Guioli; A Pragliola; B Incerti; B Bardoni; R Tonlorenzi; R Carrozzo; E Maestrini; M Pieretti; P Taillon-Miller; C J Brown; H F Willard; C Lawrence; M Graziella Persico; G Camerino; A Ballabio
Journal: Nature Date: 1991-10-10 Impact factor: 49.962

3. A family with hypogonadotropic hypogonadism and mutations in the gonadotropin-releasing hormone receptor.

Authors: N de Roux; J Young; M Misrahi; R Genet; P Chanson; G Schaison; E Milgrom
Journal: N Engl J Med Date: 1997-11-27 Impact factor: 91.245

4. Mutations in gonadotropin-releasing hormone receptor gene cause hypogonadotropic hypogonadism.

Authors: L C Layman; D P Cohen; M Jin; J Xie; Z Li; R H Reindollar; S Bolbolan; D P Bick; R R Sherins; L W Duck; L C Musgrove; J C Sellers; J D Neill
Journal: Nat Genet Date: 1998-01 Impact factor: 38.330

5. Kisspeptin directly stimulates gonadotropin-releasing hormone release via G protein-coupled receptor 54.

Authors: Sophie Messager; Emmanouella E Chatzidaki; Dan Ma; Alan G Hendrick; Dirk Zahn; John Dixon; Rosemary R Thresher; Isabelle Malinge; Didier Lomet; Mark B L Carlton; William H Colledge; Alain Caraty; Samuel A J R Aparicio
Journal: Proc Natl Acad Sci U S A Date: 2005-01-21 Impact factor: 11.205

6. Increased hypothalamic GPR54 signaling: a potential mechanism for initiation of puberty in primates.

Authors: Muhammad Shahab; Claudio Mastronardi; Stephanie B Seminara; William F Crowley; Sergio R Ojeda; Tony M Plant
Journal: Proc Natl Acad Sci U S A Date: 2005-01-31 Impact factor: 11.205

Review 7. The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily.

Authors: T P Burris; W Guo; E R McCabe
Journal: Recent Prog Horm Res Date: 1996

8. Advanced vaginal opening and precocious activation of the reproductive axis by KiSS-1 peptide, the endogenous ligand of GPR54.

Authors: V M Navarro; R Fernández-Fernández; J M Castellano; J Roa; A Mayen; M L Barreiro; F Gaytan; E Aguilar; L Pinilla; C Dieguez; M Tena-Sempere
Journal: J Physiol Date: 2004-10-14 Impact factor: 5.182

9. Developmental and hormonally regulated messenger ribonucleic acid expression of KiSS-1 and its putative receptor, GPR54, in rat hypothalamus and potent luteinizing hormone-releasing activity of KiSS-1 peptide.

Authors: V M Navarro; J M Castellano; R Fernández-Fernández; M L Barreiro; J Roa; J E Sanchez-Criado; E Aguilar; C Dieguez; L Pinilla; M Tena-Sempere
Journal: Endocrinology Date: 2004-07-08 Impact factor: 4.736

10. Characterization of the potent luteinizing hormone-releasing activity of KiSS-1 peptide, the natural ligand of GPR54.

Authors: V M Navarro; J M Castellano; R Fernández-Fernández; S Tovar; J Roa; A Mayen; R Nogueiras; M J Vazquez; M L Barreiro; P Magni; E Aguilar; C Dieguez; L Pinilla; M Tena-Sempere
Journal: Endocrinology Date: 2004-09-16 Impact factor: 4.736

28 in total

Review 1. Recent discoveries on the control of gonadotrophin-releasing hormone neurones in nonhuman primates.

Authors: E Terasawa; J R Kurian; K A Guerriero; B P Kenealy; E D Hutz; K L Keen
Journal: J Neuroendocrinol Date: 2010-05-08 Impact factor: 3.627

2. Female reproductive maturation in the absence of kisspeptin/GPR54 signaling.

Authors: Christian Mayer; Ulrich Boehm
Journal: Nat Neurosci Date: 2011-04-24 Impact factor: 24.884

3. The neurokinin B pathway in human reproduction.

Authors: Ana Claudia Latronico
Journal: Nat Genet Date: 2009-03 Impact factor: 38.330

4. Kisspeptin-10 inhibits proliferation and regulates lipolysis and lipogenesis processes in 3T3-L1 cells and isolated rat adipocytes.

Authors: Ewa Pruszyńska-Oszmałek; Paweł A Kołodziejski; Maciej Sassek; Joanna H Sliwowska
Journal: Endocrine Date: 2017-02-13 Impact factor: 3.633

Review 5. Isolated GnRH deficiency: a disease model serving as a unique prism into the systems biology of the GnRH neuronal network.

Authors: Ravikumar Balasubramanian; William F Crowley
Journal: Mol Cell Endocrinol Date: 2011-07-12 Impact factor: 4.102