BACKGROUND: The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method (Siemens Medical Solutions Diagnostics SrL) in healthy subjects and to characterize its relation to gender, age, as well as to N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP). METHODS: A Caucasian population of 692 healthy subjects (311 males and 381 females) with a mean (SD) age of 45.3 (17.3) years [range 11-89 years; females 46.5 (17.3) years, males 43.8 (17.1) years] was enrolled. The presence of cardiac or systemic acute or chronic diseases was excluded by history and accurate clinical evaluation. RESULTS: A significant difference was found between the cTnI values in men and women (men: median 0.012 microg/L, range from undetectable values to 0.196 microg/L; women: median 0.008 microg/L, range from undetectable values to 0.130 microg/L; p<0.0001 by Mann-Whitney U-test). When a multiple regression analysis was performed, NT-proBNP, gender and age significantly contributed to the regression with cTnI (R=0.444, p<0.0001). CONCLUSIONS: Our data indicate that cut-off values, based on the 99th percentile of cTnI distribution in apparently healthy subjects, can significantly vary according to age and gender of the reference population.
BACKGROUND: The aim of this study was to evaluate the distribution of cardiac troponin I (cTnI) values, measured by the ADVIA TnI-Ultra method (Siemens Medical Solutions Diagnostics SrL) in healthy subjects and to characterize its relation to gender, age, as well as to N-terminal fragment of pro-brain natriuretic peptide (NT-proBNP). METHODS: A Caucasian population of 692 healthy subjects (311 males and 381 females) with a mean (SD) age of 45.3 (17.3) years [range 11-89 years; females 46.5 (17.3) years, males 43.8 (17.1) years] was enrolled. The presence of cardiac or systemic acute or chronic diseases was excluded by history and accurate clinical evaluation. RESULTS: A significant difference was found between the cTnI values in men and women (men: median 0.012 microg/L, range from undetectable values to 0.196 microg/L; women: median 0.008 microg/L, range from undetectable values to 0.130 microg/L; p<0.0001 by Mann-Whitney U-test). When a multiple regression analysis was performed, NT-proBNP, gender and age significantly contributed to the regression with cTnI (R=0.444, p<0.0001). CONCLUSIONS: Our data indicate that cut-off values, based on the 99th percentile of cTnI distribution in apparently healthy subjects, can significantly vary according to age and gender of the reference population.
Authors: Geoffrey S Baird; Sally K Nelson; Tracy R Keeney; Alex Stewart; Stephen Williams; Stephan Kraemer; Elaine R Peskind; Thomas J Montine Journal: Am J Pathol Date: 2011-11-26 Impact factor: 4.307
Authors: Juyong Brian Kim; Yukari Kobayashi; Kegan J Moneghetti; Daniel A Brenner; Ryan O'Malley; Ingela Schnittger; Joseph C Wu; Gillian Murtagh; Agim Beshiri; Michael Fischbein; D Craig Miller; David Liang; Alan C Yeung; Francois Haddad; William F Fearon Journal: Circ Cardiovasc Interv Date: 2017-12 Impact factor: 6.546
Authors: Alessandra Barassi; Raffaele Pezzilli; Antonio Maria Morselli-Labate; Elena Dozio; Luca Massaccesi; Francesca Ghilardi; Clara Anna Linda Damele; Giovanni Maria Colpi; Gian Vico Melzi d'Eril; Massimiliano Marco Corsi Romanelli Journal: Dis Markers Date: 2015-04-16 Impact factor: 3.434