Literature DB >> 18600828

Ring-closing metathesis in the synthesis of BC ring-systems of taxol.

Cong Ma1, Stéphanie Schiltz, Xavier F Le Goff, Joëlle Prunet.   

Abstract

BC ring-systems of taxol with different or no protecting group for the C1,C2-diol moiety have been efficiently synthesized. The eight-membered B ring is formed by a ring-closing metathesis reaction (RCM) between the C10 and C11 carbon atoms. The influence of the 1,2-diol protecting group on the RCM reaction has been studied in detail.

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Year:  2008        PMID： 18600828     DOI： 10.1002/chem.200800774

Source DB:  PubMed          Journal:  Chemistry        ISSN： 0947-6539            Impact factor:   5.236


  3 in total

1.  An expeditious total synthesis of both diastereoisomeric lipid dihydroxytetrahydrofurans from Notheia anomala.

Authors:  Sudeshna Roy; Christopher D Spilling
Journal:  Org Lett       Date:  2012-04-16       Impact factor: 6.005

Review 2.  Construction of eight-membered carbocycles with trisubstituted double bonds using the ring closing metathesis reaction.

Authors:  Motoo Tori; Reiko Mizutani
Journal:  Molecules       Date:  2010-06-11       Impact factor: 4.411

3.  Cascade Metathesis Reactions for the Synthesis of Taxane and Isotaxane Derivatives.

Authors:  Cong Ma; Aurélien Letort; Rémi Aouzal; Antonia Wilkes; Gourhari Maiti; Louis J Farrugia; Louis Ricard; Joëlle Prunet
Journal:  Chemistry       Date:  2016-04-08       Impact factor: 5.236
  3 in total

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