Literature DB >> 1860069

Epidermal growth factor enhances short-term potentiation and facilitates induction of long-term potentiation in rat hippocampal slices.

K Abe1, F J Xie, H Saito.   

Abstract

Effects of recombinant human epidermal growth factor (hEGF) on short-term potentiation (STP) of evoked potential were investigated in Schaffer/commissural-CA1 pyramidal cell synapses of rat hippocampal slices. Perfusion of hEGF (6-60 ng/ml) significantly enhanced the STP induced by shorter tetanus (11 impulses at 100 Hz) in a concentration-dependent manner and the effect resulted in generation of long-term potentiation (LTP). The results suggest that hEGF can activate the mechanisms related to induction of LTP.

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Year:  1991        PMID： 1860069     DOI： 10.1016/0006-8993(91)90589-n

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

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3.  Growth factor receptor tyrosine kinases acutely regulate neuronal sodium channels through the src signaling pathway.

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Journal:  J Neurosci       Date:  1999-01-01       Impact factor: 6.167

Review 5.  Growth factor signaling and memory formation: temporal and spatial integration of a molecular network.

Authors:  Ashley M Kopec; Thomas J Carew
Journal:  Learn Mem       Date:  2013-09-16       Impact factor: 2.460

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Review 7.  Epidermal Growth Factor in the CNS: A Beguiling Journey from Integrated Cell Biology to Multiple Sclerosis. An Extensive Translational Overview.

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Journal:  Cell Mol Neurobiol       Date:  2020-11-05       Impact factor: 5.046
  7 in total

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