Literature DB >> 18600580

PDEs as drug targets for CNS immune disorders.

Andrea L O Hebb1, Harold A Robertson.   

Abstract

PDEs are important second messenger systems governing a host of cellular functions involved in neural signal transduction in the CNS and inflammatory cell signaling in the immune system. The contributions of PDE family members as novel treatments that target neuroinflammation as a pathophysiological process in the neuropathogenesis of diverse neurological and psychiatric brain disorders with prominent immune system correlates are discussed.

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Year:  2008        PMID： 18600580

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  3 in total

1.  Peroxisome proliferator-activated receptor-γ (PPAR-γ) activation confers functional neuroprotection in global ischemia.

Authors:  Zahra Fatehi-Hassanabad; R A Tasker
Journal:  Neurotox Res       Date:  2010-06-04       Impact factor: 3.911

2.  Crosstalk between phosphodiesterase 7 and glycogen synthase kinase-3: two relevant therapeutic targets for neurological disorders.

Authors:  Jose A Morales-Garcia; Valle Palomo; Miriam Redondo; Sandra Alonso-Gil; Carmen Gil; Ana Martinez; Ana Perez-Castillo
Journal:  ACS Chem Neurosci       Date:  2014-01-17       Impact factor: 4.418

3.  Phosphodiesterase Inhibition and Regulation of Dopaminergic Frontal and Striatal Functioning: Clinical Implications.

Authors:  Pim R A Heckman; Marlies A van Duinen; Eva P P Bollen; Akinori Nishi; Lawrence P Wennogle; Arjan Blokland; Jos Prickaerts
Journal:  Int J Neuropsychopharmacol       Date:  2016-04-02       Impact factor: 5.176
  3 in total

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