Literature DB >> 18600576

Linking calcium-channel isoforms to potential therapies.

Francesco Belardetti1, Gerald W Zamponi.   

Abstract

Voltage-gated calcium channels underlie a plethora of physiological functions in the cardiovascular and nervous systems. Calcium channels are considered important targets for the treatment of conditions such as absence epilepsy and hypertension, and significant efforts are increasing to discover novel calcium-channel modulators for the treatment of pain. An overview of advances in the development of calcium-channel therapeutics in the areas of pain, epilepsy and disorders associated with cardiovascular function are discussed.

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Year:  2008        PMID： 18600576

Source DB:  PubMed          Journal:  Curr Opin Investig Drugs        ISSN： 1472-4472


  11 in total

Review 1.  Low-voltage-activated T-type Ca2+ channel inhibitors as new tools in the treatment of glioblastoma: the role of endostatin.

Authors:  Yuan Zhang; Hua Wang; Zhiyuan Qian; Bo Feng; Xianyang Zhao; Xinghong Jiang; Jin Tao
Journal:  Pflugers Arch       Date:  2014-01-10       Impact factor: 3.657

Review 2.  Signaling complexes of voltage-gated calcium channels.

Authors:  Ray W Turner; Dustin Anderson; Gerald W Zamponi
Journal:  Channels (Austin)       Date:  2011-09-01       Impact factor: 2.581

3.  Optimization of ADME Properties for Sulfonamides Leading to the Discovery of a T-Type Calcium Channel Blocker, ABT-639.

Authors:  Qingwei Zhang; Zhiren Xia; Shailen Joshi; Victoria E Scott; Michael F Jarvis
Journal:  ACS Med Chem Lett       Date:  2015-04-28       Impact factor: 4.345

Review 4.  The expanding roles and mechanisms of G protein-mediated presynaptic inhibition.

Authors:  Zack Zurawski; Yun Young Yim; Simon Alford; Heidi E Hamm
Journal:  J Biol Chem       Date:  2019-02-01       Impact factor: 5.157

Review 5.  Alternative splicing: functional diversity among voltage-gated calcium channels and behavioral consequences.

Authors:  Diane Lipscombe; Arturo Andrade; Summer E Allen
Journal:  Biochim Biophys Acta       Date:  2012-09-26

6.  Cyclic Peptides as T-Type Calcium Channel Blockers: Characterization and Molecular Mapping of the Binding Site.

Authors:  Anne-Sophie Depuydt; Jérôme Rihon; Olivier Cheneval; Michiel Vanmeert; Christina I Schroeder; David J Craik; Eveline Lescrinier; Steve Peigneur; Jan Tytgat
Journal:  ACS Pharmacol Transl Sci       Date:  2021-06-07

Review 7.  Targeting voltage-gated calcium channels for neuropathic pain management.

Authors:  Danielle Perret; Z David Luo
Journal:  Neurotherapeutics       Date:  2009-10       Impact factor: 7.620

Review 8.  Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation.

Authors:  M C Iftinca
Journal:  J Med Life       Date:  2011-05-25

9.  The Concise Guide to PHARMACOLOGY 2013/14: ion channels.

Authors:  Stephen P H Alexander; Helen E Benson; Elena Faccenda; Adam J Pawson; Joanna L Sharman; William A Catterall; Michael Spedding; John A Peters; Anthony J Harmar
Journal:  Br J Pharmacol       Date:  2013-12       Impact factor: 8.739

10.  In silico identification of T-type calcium channel blockers: A ligand-based pharmacophore mapping approach.

Authors:  Tamanna Gandhi; Anu R Melge; C Gopi Mohan
Journal:  J Adv Res       Date:  2016-09-16       Impact factor: 10.479
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