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Literature DB >> 18600537

Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine.

Linda F Thompson¹, Masahide Takedachi, Yukihiko Ebisuno, Toshiyuki Tanaka, Masayuki Miyasaka, Jeffery H Mills, Margaret S Bynoe.

Abstract

CD73-deficient mice are valuable for evaluating the ability of CD73-generated adenosine to modulate adenosine receptor-mediated responses. Here we report the role of CD73 in regulating lymphocyte migration across two distinct barriers. In the first case, CD73-generated adenosine restricts the migration of lymphocytes across high endothelial venules (HEV) into draining lymph nodes after an inflammatory stimulus, apparently by triggering A(2B) receptors on HEV. Secondly, CD73 promotes the migration of pathogenic T cells into the central nervous system during experimental autoimmune encephalomyelitis. Experiments are in progress to determine whether this effect is also adenosine receptor-mediated and to identify the relevant adenosine receptor.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
5'-Nucleotidase
Adenosine

Year: 2008 PMID： 18600537 PMCID： PMC2776682 DOI： 10.1080/15257770802145678

Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381

6 in total

Review 1. Adenosine receptors.

Authors: T M Palmer; G L Stiles
Journal: Neuropharmacology Date: 1995-07 Impact factor: 5.250

2. CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism.

Authors: L Airas; J Niemelä; S Jalkanen
Journal: J Immunol Date: 2000-11-15 Impact factor: 5.422

3. Opposite effect of cAMP signaling in endothelial barriers of different origin.

Authors: K Bindewald; D Gündüz; F Härtel; S C Peters; C Rodewald; S Nau; M Schäfer; J Neumann; H M Piper; T Noll
Journal: Am J Physiol Cell Physiol Date: 2004-11 Impact factor: 4.249

4. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia.

Authors: Linda F Thompson; Holger K Eltzschig; Juan C Ibla; C Justin Van De Wiele; Regina Resta; Julio C Morote-Garcia; Sean P Colgan
Journal: J Exp Med Date: 2004-12-06 Impact factor: 14.307

5. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.

Authors: Eiji Umemoto; Toshiyuki Tanaka; Hidenobu Kanda; Soojung Jin; Kazuo Tohya; Kazuhiro Otani; Takahiro Matsutani; Masanori Matsumoto; Yukihiko Ebisuno; Myoung Ho Jang; Minoru Fukuda; Takako Hirata; Masayuki Miyasaka
Journal: J Exp Med Date: 2006-06-05 Impact factor: 14.307

6. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts.

Authors: Valeria V Orlova; Matina Economopoulou; Florea Lupu; Sentot Santoso; Triantafyllos Chavakis
Journal: J Exp Med Date: 2006-11-20 Impact factor: 14.307

6 in total

12 in total

1. Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

Authors: Florian Wirsdörfer; Simone de Leve; Federica Cappuccini; Therese Eldh; Alina V Meyer; Eva Gau; Linda F Thompson; Ning-Yuan Chen; Harry Karmouty-Quintana; Ute Fischer; Michael Kasper; Diana Klein; Jerry W Ritchey; Michael R Blackburn; Astrid M Westendorf; Martin Stuschke; Verena Jendrossek
Journal: Cancer Res Date: 2016-02-26 Impact factor: 12.701

2. Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis.

Authors: Irena Lavrnja; Danijela Laketa; Danijela Savic; Iva Bozic; Ivana Bjelobaba; Sanja Pekovic; Nadezda Nedeljkovic
Journal: J Mol Neurosci Date: 2014-10-19 Impact factor: 3.444

Review 3. CD39 and CD73 in immunity and inflammation.

Authors: Luca Antonioli; Pál Pacher; E Sylvester Vizi; György Haskó
Journal: Trends Mol Med Date: 2013-04-17 Impact factor: 11.951

4. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis.

Authors: Jeffrey H Mills; Linda F Thompson; Cynthia Mueller; Adam T Waickman; Sirpa Jalkanen; Jussi Niemela; Laura Airas; Margaret S Bynoe
Journal: Proc Natl Acad Sci U S A Date: 2008-06-30 Impact factor: 11.205

Regulation of leukocyte migration across endothelial barriers by ECTO-5'-nucleotidase-generated adenosine.

Review 1. Adenosine receptors.

2. CD73 engagement promotes lymphocyte binding to endothelial cells via a lymphocyte function-associated antigen-1-dependent mechanism.

3. Opposite effect of cAMP signaling in endothelial barriers of different origin.

4. Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia.

5. Nepmucin, a novel HEV sialomucin, mediates L-selectin-dependent lymphocyte rolling and promotes lymphocyte adhesion under flow.

6. Junctional adhesion molecule-C regulates vascular endothelial permeability by modulating VE-cadherin-mediated cell-cell contacts.

1. Extracellular Adenosine Production by ecto-5'-Nucleotidase (CD73) Enhances Radiation-Induced Lung Fibrosis.

2. Expression of a second ecto-5'-nucleotidase variant besides the usual protein in symptomatic phase of experimental autoimmune encephalomyelitis.

Review 3. CD39 and CD73 in immunity and inflammation.

4. CD73 is required for efficient entry of lymphocytes into the central nervous system during experimental autoimmune encephalomyelitis.

5. Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.

Review 6. Extracellular adenosine generation in the regulation of pro-inflammatory responses and pathogen colonization.

Review 7. Targeting the Immunomodulatory CD73/Adenosine System to Improve the Therapeutic Gain of Radiotherapy.

Review 8. Generation and Function of Non-cell-bound CD73 in Inflammation.

Review 9. Adenosine receptor signaling: a key to opening the blood-brain door.

Review 10. The Phagocytic Code Regulating Phagocytosis of Mammalian Cells.