Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Urate transport across the apical membrane of renal proximal tubules.

Literature DB >> 18600508

Urate transport across the apical membrane of renal proximal tubules.

Abstract

Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or "urate transportsome," that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.

Entities: Chemical Disease Gene

Mesh：

Substances：

Year: 2008 PMID： 18600508 DOI： 10.1080/15257770802136024

Source DB: PubMed Journal: Nucleosides Nucleotides Nucleic Acids ISSN： 1525-7770 Impact factor: 1.381

Keyword Cloud
Cited

16 in total

1. Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses.

Authors: Kate Witkowska; Kyla M Smith; Sylvia Y M Yao; Amy M L Ng; Debbie O'Neill; Edward Karpinski; James D Young; Christopher I Cheeseman
Journal: Am J Physiol Renal Physiol Date: 2012-05-30

2. A sugar transporter regulates serum urate levels: implications for prevention and management of hyperuricemia in gout.

Authors: Robert A Terkeltaub
Journal: Curr Rheumatol Rep Date: 2009-04 Impact factor: 4.592

Urate transport across the apical membrane of renal proximal tubules.

1. Human SLC2A9a and SLC2A9b isoforms mediate electrogenic transport of urate with different characteristics in the presence of hexoses.

2. A sugar transporter regulates serum urate levels: implications for prevention and management of hyperuricemia in gout.

Review 3. Genetics of hyperuricemia and gout: implications for the present and future.

Review 4. Renal Drug Transporters and Drug Interactions.

5. Evidence for a role of PDZ domain-containing proteins to mediate hypophosphatemia in calcium stone formers.

Review 6. Gout. Novel therapies for treatment of gout and hyperuricemia.

7. Latest evidence on gout management: what the clinician needs to know.

Review 8. Update on gout: new therapeutic strategies and options.

Review 9. The genetics of hyperuricaemia and gout.

Review 10. Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.