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Literature DB >> 18600473

Regulation of melanin synthesis by the TGF-beta family in B16 melanoma cells.

Masaru Murakami¹, Fumihide Matsuzaki, Masayuki Funaba.

Abstract

Effects of representative members of the transforming growth factor-beta (TGF-beta) family, TGF-beta1, activin A and BMP-2, on melanin content and expression of pigment-producing enzymes were examined in B16 melanoma cells. Treatment with TGF-beta1 or activin A but not with BMP-2 significantly decreased melanin content and expression of Tyrosinase and Tyrp-1, suggesting an inhibitory effect of TGF-beta1 and activin A on melanin synthesis. TGF-beta1 completely inhibited melanin synthesis induced by alpha-melanin stimulating hormone (alpha-MSH), whereas activin A only slightly did. As compared with parental B16 cells, the inhibitory effects of TGF-beta1 and activin A on melanin content were relative smaller in B16 F10 cells, a subline of B16 cells that contain more pigment. The present study indicates that in addition to TGF-beta, activin negatively regulates melanogenesis in the absence of alpha-MSH, but that the activity in the presence of alpha-MSH was slightly different between TGF-beta and activin.

Entities: Chemical Disease Gene

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Year: 2008 PMID： 18600473 DOI： 10.1007/s11033-008-9304-6

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

16 in total

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Journal: Genes Dev Date: 2005-12-01 Impact factor: 11.361

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Journal: Annu Rev Cell Dev Biol Date: 2005 Impact factor: 13.827

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Journal: Life Sci Date: 2002-01-04 Impact factor: 5.037

Review 9. Tyrosinase and related proteins in mammalian pigmentation.

Authors: V del Marmol; F Beermann
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10. Transcriptional activation of mouse mast cell Protease-7 by activin and transforming growth factor-beta is inhibited by microphthalmia-associated transcription factor.

Authors: Masayuki Funaba; Teruo Ikeda; Masaru Murakami; Kenji Ogawa; Kunihiro Tsuchida; Hiromu Sugino; Matanobu Abe
Journal: J Biol Chem Date: 2003-10-02 Impact factor: 5.157

8 in total

1. A miR-125b binding site polymorphism in bone morphogenetic protein membrane receptor type IB gene and prostate cancer risk in China.

Authors: Ninghan Feng; Bin Xu; Jun Tao; Pengchao Li; Gong Cheng; Zhichao Min; Yuanyuan Mi; Meilin Wang; Na Tong; Jialin Tang; Zhengdong Zhang; Hongfei Wu; Wei Zhang; Zengjun Wang; Lixin Hua
Journal: Mol Biol Rep Date: 2011-05-10 Impact factor: 2.316

2. Polymorphisms of BMPR-IB gene and their relationship with litter size in goats.

Authors: M X Chu; X H Zhao; Y J Zhang; M Jin; J Y Wang; R Di; G L Cao; T Feng; L Fang; Y H Ma; K Li
Journal: Mol Biol Rep Date: 2010-03-19 Impact factor: 2.316

3. Targeted deletion of TGFβ1 in basal keratinocytes causes profound defects in stratified squamous epithelia and aberrant melanocyte migration.

Authors: Fiona E Chalmers; Justyn E Dusold; Javed A Shaik; Hailey A Walsh; Adam B Glick
Journal: Dev Biol Date: 2022-02-25 Impact factor: 3.582

4. Evaluation of TILI-2 as an Anti-Tyrosinase, Anti-Oxidative Agent and Its Role in Preventing Melanogenesis Using a Proteomics Approach.

Authors: Anupong Joompang; Preeyanan Anwised; Sompong Klaynongsruang; Sittiruk Roytrakul; Lapatrada Taemaitree; Nisachon Jangpromma
Journal: Molecules Date: 2022-05-18 Impact factor: 4.927