Literature DB >> 18600277

Mono- and dicationic short PEG and methylene dioxyalkylglycerols for use in synthetic gene delivery systems.

Christopher A Hurley1, John B Wong, Jimmy Ho, Michele Writer, Scott A Irvine, M Jayne Lawrence, Stephen L Hart, Alethea B Tabor, Helen C Hailes.   

Abstract

A range of monocationic and dicationic dioxyalkylglycerol cytofectins have been synthesised possessing methylene and short n-ethylene glycol spacers. The monocationic compounds were found to be effective in transfections when formulated as lipopolyplexes with peptide and DNA components, in particular with shorter PEG head groups which may have less effect on peptide targeting in the ternary complex.

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Year:  2008        PMID： 18600277     DOI： 10.1039/b719702k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  5 in total

1.  Detecting intratumoral heterogeneity of EGFR activity by liposome-based in vivo transfection of a fluorescent biosensor.

Authors:  G Weitsman; N J Mitchell; R Evans; A Cheung; T L Kalber; R Bofinger; G O Fruhwirth; M Keppler; Z V F Wright; P R Barber; P Gordon; T de Koning; W Wulaningsih; K Sander; B Vojnovic; S Ameer-Beg; M Lythgoe; J N Arnold; E Årstad; F Festy; H C Hailes; A B Tabor; T Ng
Journal:  Oncogene       Date:  2017-02-06       Impact factor: 9.867

2.  Development of lipopolyplexes for gene delivery: A comparison of the effects of differing modes of targeting peptide display on the structure and transfection activities of lipopolyplexes.

Authors:  Robin Bofinger; May Zaw-Thin; Nicholas J Mitchell; P Stephen Patrick; Cassandra Stowe; Ana Gomez-Ramirez; Helen C Hailes; Tammy L Kalber; Alethea B Tabor
Journal:  J Pept Sci       Date:  2018-10-16       Impact factor: 1.905

3.  The discovery and enhanced properties of trichain lipids in lipopolyplex gene delivery systems.

Authors:  Atefeh Mohammadi; Laila Kudsiova; M Firouz Mohd Mustapa; Frederick Campbell; Danielle Vlaho; Katharina Welser; Harriet Story; Aristides D Tagalakis; Stephen L Hart; David J Barlow; Alethea B Tabor; M Jayne Lawrence; Helen C Hailes
Journal:  Org Biomol Chem       Date:  2019-01-23       Impact factor: 3.876

4.  Incorporation of paramagnetic, fluorescent and PET/SPECT contrast agents into liposomes for multimodal imaging.

Authors:  Nick Mitchell; Tammy L Kalber; Margaret S Cooper; Kavitha Sunassee; Samantha L Chalker; Karen P Shaw; Katherine L Ordidge; Adam Badar; Samuel M Janes; Philip J Blower; Mark F Lythgoe; Helen C Hailes; Alethea B Tabor
Journal:  Biomaterials       Date:  2012-11-03       Impact factor: 12.479

5.  Trichain cationic lipids: the potential of their lipoplexes for gene delivery.

Authors:  Laila Kudsiova; Atefeh Mohammadi; M Firouz Mohd Mustapa; Frederick Campbell; Katharina Welser; Danielle Vlaho; Harriet Story; David J Barlow; Alethea B Tabor; Helen C Hailes; M Jayne Lawrence
Journal:  Biomater Sci       Date:  2018-12-18       Impact factor: 6.843
  5 in total

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