PURPOSE: To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population. METHODS: Baseline lens status and risk of incident AMD (iAMD) were examined in participants of the prospective population-based Rotterdam Study at risk for AMD (n = 6032). Slit lamp examination was used to determine lens status and stereoscopic color fundus photography to determine the presence of AMD. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated with generalized estimating equation (GEE) models. Stratified analyses were also performed for CFH Y402H genotype. RESULTS: After adjusting for age, sex, follow-up time, and the correlation between eyes, a history of cataract surgery was associated with incident dry late AMD (OR, 3.43; 95% CI, 1.82-6.49). This association remained significant after additional adjustment for smoking status and AMD stage at baseline (OR, 3.44; 95% CI, 1.68-7.08). No statistically significant association was found between prior cataract surgery and the incidence of wet late AMD or early AMD. Homozygous CFH Y402H carriers had higher risks for all types of AMD compared to heterozygotes and noncarriers after cataract surgery, particularly for dry AMD. CONCLUSIONS: The findings imply that cataract surgery increases the risk of dry AMD, particularly in homozygous CFH Y402H carriers. The risk of AMD progression should be considered before recommending cataract surgery to patients with cataract and early AMD.
PURPOSE: To investigate still-controversial associations between prior cataract surgery and aging macula disorder (AMD) in a general population. METHODS: Baseline lens status and risk of incident AMD (iAMD) were examined in participants of the prospective population-based Rotterdam Study at risk for AMD (n = 6032). Slit lamp examination was used to determine lens status and stereoscopic color fundus photography to determine the presence of AMD. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated with generalized estimating equation (GEE) models. Stratified analyses were also performed for CFHY402H genotype. RESULTS: After adjusting for age, sex, follow-up time, and the correlation between eyes, a history of cataract surgery was associated with incident dry late AMD (OR, 3.43; 95% CI, 1.82-6.49). This association remained significant after additional adjustment for smoking status and AMD stage at baseline (OR, 3.44; 95% CI, 1.68-7.08). No statistically significant association was found between prior cataract surgery and the incidence of wet late AMD or early AMD. Homozygous CFHY402H carriers had higher risks for all types of AMD compared to heterozygotes and noncarriers after cataract surgery, particularly for dry AMD. CONCLUSIONS: The findings imply that cataract surgery increases the risk of dry AMD, particularly in homozygous CFHY402H carriers. The risk of AMD progression should be considered before recommending cataract surgery to patients with cataract and early AMD.
Authors: Chee Wai Wong; Jiemin Liao; Gemmy C Cheung; Chiea Chuen Khor; Eranga N Vithana; Jie Jin Wang; Paul Mitchell; Tin Aung; Tien Y Wong; Ching-Yu Cheng Journal: PLoS One Date: 2015-03-18 Impact factor: 3.240
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Authors: Albert Hofman; Monique M B Breteler; Cornelia M van Duijn; Harry L A Janssen; Gabriel P Krestin; Ernst J Kuipers; Bruno H Ch Stricker; Henning Tiemeier; André G Uitterlinden; Johannes R Vingerling; Jacqueline C M Witteman Journal: Eur J Epidemiol Date: 2009 Impact factor: 8.082
Authors: Gergely Losonczy; Attila Vajas; Lili Takács; Erika Dzsudzsák; Agnes Fekete; Eva Márhoffer; László Kardos; Eva Ajzner; Begoña Hurtado; Pablo Garcia de Frutos; András Berta; István Balogh Journal: PLoS One Date: 2012-11-29 Impact factor: 3.240