Literature DB >> 18599440

Dependence of antibody-mediated presentation of antigen on FcRn.

Shuo-Wang Qiao1, Kanna Kobayashi, Finn-Eirik Johansen, Ludvig M Sollid, Jan Terje Andersen, Edgar Milford, Derry C Roopenian, Wayne I Lencer, Richard S Blumberg.   

Abstract

The neonatal Fc receptor for IgG (FcRn) is a distant member of the MHC class I protein family. It binds IgG and albumin in a pH-dependent manner and protects these from catabolism by diverting them from a degradative fate in lysosomes. In addition, FcRn-mediated IgG transport across epithelial barriers is responsible for the transmission of IgG from mother to infant and can also enhance IgG-mediated antigen uptake across mucosal epithelia. We now show a previously undescribed role for FcRn in mediating the presentation of antigens by dendritic cells when antigens are present as a complex with antibody by uniquely directing multimeric immune complexes, but not monomeric IgG, to lysosomes.

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Year:  2008        PMID： 18599440      PMCID： PMC2453734          DOI： 10.1073/pnas.0801717105

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Cell surface recycling of internalized antigen permits dendritic cell priming of B cells.

Authors:  Amy Bergtold; Dharmesh D Desai; Anamika Gavhane; Raphael Clynes
Journal:  Immunity       Date:  2005-11       Impact factor: 31.745

2.  Neonatal Fc receptor for IgG regulates mucosal immune responses to luminal bacteria.

Authors:  Masaru Yoshida; Kanna Kobayashi; Timothy T Kuo; Lynn Bry; Jonathan N Glickman; Steven M Claypool; Arthur Kaser; Takashi Nagaishi; Darren E Higgins; Emiko Mizoguchi; Yoshio Wakatsuki; Derry C Roopenian; Atsushi Mizoguchi; Wayne I Lencer; Richard S Blumberg
Journal:  J Clin Invest       Date:  2006-08       Impact factor: 14.808

3.  Toll-dependent selection of microbial antigens for presentation by dendritic cells.

Authors:  J Magarian Blander; Ruslan Medzhitov
Journal:  Nature       Date:  2006-02-19       Impact factor: 49.962

4.  The MHC class I-related FcRn ameliorates murine Lyme arthritis.

Authors:  Helena Crowley; Joseph Alroy; Thomas J Sproule; Derry Roopenian; Brigitte T Huber
Journal:  Int Immunol       Date:  2006-01-13       Impact factor: 4.823

5.  The protection receptor for IgG catabolism is the beta2-microglobulin-containing neonatal intestinal transport receptor.

Authors:  R P Junghans; C L Anderson
Journal:  Proc Natl Acad Sci U S A       Date:  1996-05-28       Impact factor: 11.205

6.  Delineation of the amino acid residues involved in transcytosis and catabolism of mouse IgG1.

Authors:  C Medesan; D Matesoi; C Radu; V Ghetie; E S Ward
Journal:  J Immunol       Date:  1997-03-01       Impact factor: 5.422

7.  Mapping the site on human IgG for binding of the MHC class I-related receptor, FcRn.

Authors:  J K Kim; M Firan; C G Radu; C H Kim; V Ghetie; E S Ward
Journal:  Eur J Immunol       Date:  1999-09       Impact factor: 5.532

8.  Refining the rules of gliadin T cell epitope binding to the disease-associated DQ2 molecule in celiac disease: importance of proline spacing and glutamine deamidation.

Authors:  Shuo-Wang Qiao; Elin Bergseng; Oyvind Molberg; Günther Jung; Burkhard Fleckenstein; Ludvig M Sollid
Journal:  J Immunol       Date:  2005-07-01       Impact factor: 5.422

9.  Following the fate of individual T cells throughout activation and clonal expansion. Signals from T cell receptor and CD28 differentially regulate the induction and duration of a proliferative response.

Authors:  A D Wells; H Gudmundsdottir; L A Turka
Journal:  J Clin Invest       Date:  1997-12-15       Impact factor: 14.808

10.  Ligand valency affects transcytosis, recycling and intracellular trafficking mediated by the neonatal Fc receptor.

Authors:  Devin B Tesar; Noreen E Tiangco; Pamela J Bjorkman
Journal:  Traffic       Date:  2006-09       Impact factor: 6.215
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  120 in total

1.  Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human.

Authors:  Dhaval K Shah; Alison M Betts
Journal:  J Pharmacokinet Pharmacodyn       Date:  2011-12-06       Impact factor: 2.745

Review 2.  Recent advances using FcRn overexpression in transgenic animals to overcome impediments of standard antibody technologies to improve the generation of specific antibodies.

Authors:  Imre Kacskovics; Judit Cervenak; Anna Erdei; Richard A Goldsby; John E Butler
Journal:  MAbs       Date:  2011-09-01       Impact factor: 5.857

3.  MHC class I family proteins retard systemic lupus erythematosus autoimmunity and B cell lymphomagenesis.

Authors:  Caroline G McPhee; Thomas J Sproule; Dong-Mi Shin; Jason A Bubier; William H Schott; Martin P Steinbuck; Lia Avenesyan; Herbert C Morse; Derry C Roopenian
Journal:  J Immunol       Date:  2011-09-30       Impact factor: 5.422

Review 4.  Mucosal antibodies in the regulation of tolerance and allergy to foods.

Authors:  M Cecilia Berin
Journal:  Semin Immunopathol       Date:  2012-07-10       Impact factor: 9.623

5.  Antibodies to gp120 and PD-1 expression on virus-specific CD8+ T cells in protection from simian AIDS.

Authors:  Monica Vaccari; Rabih Halwani; L Jean Patterson; Adriano Boasso; Jennifer Beal; Elzbieta Tryniszewska; Anna Hryniewicz; David Venzon; Elias K Haddad; Mohamed El-Far; Margherita Rosati; George N Pavlakis; Barbara K Felber; Saleh Al-Muhsen; Marjorie Robert-Guroff; Rafick-Pierre Sekaly; Genoveffa Franchini
Journal:  J Virol       Date:  2013-01-16       Impact factor: 5.103

Review 6.  Targeting FcRn for the modulation of antibody dynamics.

Authors:  E Sally Ward; Siva Charan Devanaboyina; Raimund J Ober
Journal:  Mol Immunol       Date:  2015-03-09       Impact factor: 4.407

7.  Expression of neonatal Fc receptor in the eye.

Authors:  Michael B Powner; Jenny A G McKenzie; Gregory J Christianson; Derry C Roopenian; Marcus Fruttiger
Journal:  Invest Ophthalmol Vis Sci       Date:  2014-03-19       Impact factor: 4.799

8.  Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding.

Authors:  Jan Terje Andersen; Muluneh Bekele Daba; Gøril Berntzen; Terje E Michaelsen; Inger Sandlie
Journal:  J Biol Chem       Date:  2009-12-14       Impact factor: 5.157

Review 9.  Targeting FcRn to Generate Antibody-Based Therapeutics.

Authors:  E Sally Ward; Raimund J Ober
Journal:  Trends Pharmacol Sci       Date:  2018-08-22       Impact factor: 14.819

Review 10.  Cross-presentation of IgG-containing immune complexes.

Authors:  Kristi Baker; Timo Rath; Wayne I Lencer; Edda Fiebiger; Richard S Blumberg
Journal:  Cell Mol Life Sci       Date:  2012-07-31       Impact factor: 9.261
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