Literature DB >> 1859854

A second messenger RNA species of transforming growth factor beta 1 in infarcted rat heart.

S W Qian1, P Kondaiah, W Casscells, A B Roberts, M B Sporn.   

Abstract

Transforming growth factor-beta 1 (TGF-beta 1) is encoded predominantly by a 2.4-kb mRNA in most tissues. However, an additional transcript of 1.9 kb can be detected in rat heart after experimental myocardial infarction caused by ligation of the left coronary artery. This transcript level is significantly higher in infarcted heart tissue than in normal heart tissue, suggesting an important role for this mRNA species in response to injury. Structural characterization of the 1.9-kb mRNA showed that it included the entire coding sequence present in the 2.4-kb TGF-beta 1 mRNA, but also contained an additional nonhomologous 3'-untranslated region (UTR). The junction between the shared and unique 3' sequence in the 1.9-kb mRNA occurred only two nucleotides before the proposed polyadenylation site of the rat TGF-beta 1 2.4-kb mRNA. The unique 3'-UTR and the deduced shortened 5'-UTR in the novel 1.9-kb TGF-beta 1 mRNA suggest different transcriptional and translational regulatory mechanisms under conditions of tissue injury.

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Year:  1991        PMID： 1859854      PMCID： PMC361760          DOI： 10.1091/mbc.2.3.241

Source DB:  PubMed          Journal:  Cell Regul        ISSN： 1044-2030


  27 in total

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Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

4.  Transforming growth factor beta mRNA increases during liver regeneration: a possible paracrine mechanism of growth regulation.

Authors:  L Braun; J E Mead; M Panzica; R Mikumo; G I Bell; N Fausto
Journal:  Proc Natl Acad Sci U S A       Date:  1988-03       Impact factor: 11.205

5.  A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta.

Authors:  P Rossi; G Karsenty; A B Roberts; N S Roche; M B Sporn; B de Crombrugghe
Journal:  Cell       Date:  1988-02-12       Impact factor: 41.582

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Journal:  Proc Natl Acad Sci U S A       Date:  1984-04       Impact factor: 11.205

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Authors:  C L Manthey; J B Allen; L R Ellingsworth; S M Wahl
Journal:  Growth Factors       Date:  1990       Impact factor: 2.511

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Authors:  A G Geiser; S J Kim; A B Roberts; M B Sporn
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

9.  Localized production of TGF-beta mRNA in tumour promoter-stimulated mouse epidermis.

Authors:  R J Akhurst; F Fee; A Balmain
Journal:  Nature       Date:  1988-01-28       Impact factor: 49.962

10.  Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.

Authors:  J Varga; J Rosenbloom; S A Jimenez
Journal:  Biochem J       Date:  1987-11-01       Impact factor: 3.857
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  10 in total

Review 1.  An analysis of vertebrate mRNA sequences: intimations of translational control.

Authors:  M Kozak
Journal:  J Cell Biol       Date:  1991-11       Impact factor: 10.539

2.  A GC-rich domain with bifunctional effects on mRNA and protein levels: implications for control of transforming growth factor beta 1 expression.

Authors:  L Scotto; R K Assoian
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

3.  Selective growth arrest and phenotypic reversion of prostate cancer cells in vitro by nontoxic pharmacological concentrations of phenylacetate.

Authors:  D Samid; S Shack; C E Myers
Journal:  J Clin Invest       Date:  1993-05       Impact factor: 14.808

4.  In vivo stimulation of connective tissue accumulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+ in rat experimental wounds.

Authors:  F X Maquart; G Bellon; B Chaqour; J Wegrowski; L M Patt; R E Trachy; J C Monboisse; F Chastang; P Birembaut; P Gillery
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

5.  Regulation of mRNA transcripts and DNA synthesis in the rat heart following intravenous injection of transforming growth factor beta 1.

Authors:  A Sigel; J A Douglas; M Eghbali-Webb
Journal:  Mol Cell Biochem       Date:  1994-12-21       Impact factor: 3.396

6.  Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3.

Authors:  Y J Bang; S J Kim; D Danielpour; M A O'Reilly; K Y Kim; C E Myers; J B Trepel
Journal:  Proc Natl Acad Sci U S A       Date:  1992-04-15       Impact factor: 11.205

7.  Hypertrophic stimuli induce transforming growth factor-beta 1 expression in rat ventricular myocytes.

Authors:  N Takahashi; A Calderone; N J Izzo; T M Mäki; J D Marsh; W S Colucci
Journal:  J Clin Invest       Date:  1994-10       Impact factor: 14.808

8.  Independent regulation of transforming growth factor-beta1 transcription and translation by glucose and platelet-derived growth factor.

Authors:  Donald Fraser; Lalage Wakefield; Aled Phillips
Journal:  Am J Pathol       Date:  2002-09       Impact factor: 4.307

9.  Translational regulation of renal proximal tubular epithelial cell transforming growth factor-beta1 generation by insulin.

Authors:  K Morrisey; R A Evans; L Wakefield; A O Phillips
Journal:  Am J Pathol       Date:  2001-11       Impact factor: 4.307

Review 10.  Transforming growth factor-beta: recent progress and new challenges.

Authors:  M B Sporn; A B Roberts
Journal:  J Cell Biol       Date:  1992-12       Impact factor: 10.539
  10 in total

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