Literature DB >> 1859757

Thiopentone-propofol hypnotic synergism in patients.

M Naguib1, A Sari-Kouzel.   

Abstract

The hypnotic effects of thiopentone, propofol and their combination were studied in 120 unpremedicated ASA group I patients. The end-point for induction of anaesthesia was taken as inability to open the eyes to command 60 s after the end of injection. The dose-response curves were determined by probit analysis. Isobolographic and algebraic (fractional) analyses were used to assess quantitatively the combined hypnotic effect of thiopentone and propofol and to define the type of interaction between these two drugs. The interaction between thiopentone and propofol was found to be synergistic.

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Year:  1991        PMID： 1859757     DOI： 10.1093/bja/67.1.4

Source DB:  PubMed          Journal:  Br J Anaesth        ISSN： 0007-0912            Impact factor:   9.166


  6 in total

1.  The chemical and physical stability of a 1:1 mixture of propofol and methohexital.

Authors:  J Bennett; J Gross; F Nichols; N Chidambaram; D Burgess
Journal:  Anesth Prog       Date:  2001

Review 2.  Propofol. An update of its use in anaesthesia and conscious sedation.

Authors:  H M Bryson; B R Fulton; D Faulds
Journal:  Drugs       Date:  1995-09       Impact factor: 9.546

Review 3.  Propofol. An overview of its pharmacology and a review of its clinical efficacy in intensive care sedation.

Authors:  B Fulton; E M Sorkin
Journal:  Drugs       Date:  1995-10       Impact factor: 9.546

4.  Recovery characteristics following induction of anaesthesia with a combination of thiopentone and propofol.

Authors:  S Rashiq; B Gallant; M Grace; D T Jolly
Journal:  Can J Anaesth       Date:  1994-12       Impact factor: 5.063

5.  Comparison of propofol (1%) with admixture (1:1) of thiopentone (1.25%) and propofol (0.5%) for laryngeal mask airway insertion in children undergoing elective eye surgery: Double-masked randomized clinical trial.

Authors:  Renu Sinha; Dilip Shende; Rakesh Garg
Journal:  Indian J Anaesth       Date:  2010-03

6.  Ideal anesthetic agents for day-care gynecological procedures: A clinical trial comparing thiopentone with ketamine as adjuncts to propofol.

Authors:  Hemani Ahuja; Valsamma Abraham; John Abraham; Dootika Liddle
Journal:  Adv Biomed Res       Date:  2015-05-11
  6 in total

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