Literature DB >> 18597534

Stereoselective bioreduction of bulky-bulky ketones by a novel ADH from Ralstonia sp.

Iván Lavandera1, Alexander Kern, Bianca Ferreira-Silva, Anton Glieder, Stefaan de Wildeman, Wolfgang Kroutil.   

Abstract

Ketones with two bulky substituents, named bulky-bulky ketones, as well as less sterically demanding ketones were successfully reduced to the corresponding optically highly enriched alcohols using a novel identified recombinant short-chain alcohol dehydrogenase RasADH from Ralstonia sp. DSM 6428 overexpressed in E. coli.

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Year:  2008        PMID： 18597534     DOI： 10.1021/jo800849d

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  9 in total

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2.  Chemoenzymatic Oxosulfonylation-Bioreduction Sequence for the Stereoselective Synthesis of β-Hydroxy Sulfones.

Authors:  Marina López-Agudo; Nicolás Ríos-Lombardía; Javier González-Sabín; Iván Lavandera; Vicente Gotor-Fernández
Journal:  ChemSusChem       Date:  2021-08-19       Impact factor: 9.140

3.  Tailoring the properties of (catalytically)-active inclusion bodies.

Authors:  V D Jäger; R Kloss; A Grünberger; S Seide; D Hahn; T Karmainski; M Piqueray; J Embruch; S Longerich; U Mackfeld; K-E Jaeger; W Wiechert; M Pohl; U Krauss
Journal:  Microb Cell Fact       Date:  2019-02-07       Impact factor: 5.328

4.  Synthesis of α-hydroxy ketones and vicinal (R,R)-diols by Bacillus clausii DSM 8716T butanediol dehydrogenase.

Authors:  Lukas Muschallik; Denise Molinnus; Melanie Jablonski; Carina Ronja Kipp; Johannes Bongaerts; Martina Pohl; Torsten Wagner; Michael J Schöning; Thorsten Selmer; Petra Siegert
Journal:  RSC Adv       Date:  2020-03-25       Impact factor: 3.361

Review 5.  High-Yield Synthesis of Enantiopure 1,2-Amino Alcohols from l-Phenylalanine via Linear and Divergent Enzymatic Cascades.

Authors:  Maria L Corrado; Tanja Knaus; Ulrich Schwaneberg; Francesco G Mutti
Journal:  Org Process Res Dev       Date:  2022-03-28       Impact factor: 3.858

6.  Development of a novel chemoenzymatic route to enantiomerically enriched β-adrenolytic agents. A case study toward propranolol, alprenolol, pindolol, carazolol, moprolol, and metoprolol.

Authors:  Paweł Borowiecki; Beata Zdun; Natalia Popow; Magdalena Wiklińska; Tamara Reiter; Wolfgang Kroutil
Journal:  RSC Adv       Date:  2022-08-10       Impact factor: 4.036

7.  Synthesis of Optically Active syn- and anti-Chlorohydrins through a Bienzymatic Reductive Cascade.

Authors:  Jorge González-Rodríguez; Jesús Albarrán-Velo; Raquel G Soengas; Iván Lavandera; Vicente Gotor-Fernández; Humberto Rodríguez-Solla
Journal:  Org Lett       Date:  2022-09-26       Impact factor: 6.072

8.  Conversion of alcohols to enantiopure amines through dual-enzyme hydrogen-borrowing cascades.

Authors:  Francesco G Mutti; Tanja Knaus; Nigel S Scrutton; Michael Breuer; Nicholas J Turner
Journal:  Science       Date:  2015-09-25       Impact factor: 47.728

9.  Structure-guided design of Serratia marcescens short-chain dehydrogenase/reductase for stereoselective synthesis of (R)-phenylephrine.

Authors:  Jai-Shin Liu; Yi-Chia Kuan; Yu Tsou; Tung-Yueh Lin; Wen-Hwei Hsu; Ming-Te Yang; Jong-Yih Lin; Wen-Ching Wang
Journal:  Sci Rep       Date:  2018-02-02       Impact factor: 4.379
  9 in total

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