Literature DB >> 18596840

Enantioselective Transaminations by Dendrimeric Enzyme Mimics.

Ronald Breslow1, Sujun Wei, Craig Kenesky.   

Abstract

PAMAM dendrimers have been constructed with a pyridoxamine core, and chiral capping amino groups. Transamination to form phenylalanine and alanine from their related ketoacids produced enantioselectivities induced by the formally remote chiral caps, supporting computer models that indicate folding of the dendrimer chains back into the core region.

Entities:  

Year:  2007        PMID： 18596840      PMCID： PMC2031867          DOI： 10.1016/j.tet.2007.02.052

Source DB:  PubMed          Journal:  Tetrahedron        ISSN： 0040-4020            Impact factor:   2.457


  11 in total

1.  Reversal of optical induction in transamination by regioisomeric bifunctionalized cyclodextrins.

Authors:  E Fasella; S D Dong; R Breslow
Journal:  Bioorg Med Chem       Date:  1999-05       Impact factor: 3.641

2.  Stereoselectivity in reactions of amino acids catalyzed by pyridoxal derivatives carrying rigidly-attached chirally-mounted basic groups--transamination, racemization, decarboxylation, retro-aldol reaction, and aldol condensation.

Authors:  Lei Liu; Mary Rozenman; Ronald Breslow
Journal:  Bioorg Med Chem       Date:  2002-12       Impact factor: 3.641

3.  Water exclusion and enantioselectivity in catalysis.

Authors:  Ronald Breslow; Subhajit Bandyopadhyay; Mindy Levine; Wenjun Zhou
Journal:  Chembiochem       Date:  2006-10       Impact factor: 3.164

4.  Chiral polyamines from reduction of polypeptides: asymmetric pyridoxamine-mediated transaminations.

Authors:  Wenjun Zhou; Nancy Yerkes; Jason J Chruma; Lei Liu; Ronald Breslow
Journal:  Bioorg Med Chem Lett       Date:  2005-03-01       Impact factor: 2.823

5.  Hydrophobic and electronic factors in the design of dialkylglycine decarboxylase mimics.

Authors:  Jason J Chruma; Lei Liu; Wenjun Zhou; Ronald Breslow
Journal:  Bioorg Med Chem       Date:  2005-10-15       Impact factor: 3.641

6.  A potent polymer/pyridoxamine enzyme mimic.

Authors:  Lei Liu; Ronald Breslow
Journal:  J Am Chem Soc       Date:  2002-05-08       Impact factor: 15.419

7.  A racemization test in peptide synthesis using 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM).

Authors:  Munetaka Kunishima; Akiko Kitao; Chiho Kawachi; Yasunobu Watanabe; Shin Iguchi; Kazuhito Hioki; Shohei Tani
Journal:  Chem Pharm Bull (Tokyo)       Date:  2002-04       Impact factor: 1.645

8.  Dendrimeric pyridoxamine enzyme mimics.

Authors:  Lei Liu; Ronald Breslow
Journal:  J Am Chem Soc       Date:  2003-10-08       Impact factor: 15.419

9.  Hexadeoxycycloheptaamylose-pyridoxamine, an artificial transaminase with a "deeper" binding pocket.

Authors:  A W Czarnik; R Breslow
Journal:  Carbohydr Res       Date:  1984-05-15       Impact factor: 2.104

10.  Transamination reactions with multiple turnovers catalyzed by hydrophobic pyridoxamine cofactors in the presence of polyethylenimine polymers.

Authors:  Lei Liu; Wenjun Zhou; Jason Chruma; Ronald Breslow
Journal:  J Am Chem Soc       Date:  2004-07-07       Impact factor: 15.419
View more
  1 in total

1.  Bioconjugates of PAMAM dendrimers with trans-retinal, pyridoxal, and pyridoxal phosphate.

Authors:  A Filipowicz; S Wołowiec
Journal:  Int J Nanomedicine       Date:  2012-09-06
  1 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.