BACKGROUND: The causes of chronic cough in elderly patients have not been specifically investigated. Therefore, it remains to be determined whether chronic cough differs between elderly and non-elderly patients. OBJECTIVES: To investigate the distribution of causes of chronic cough in elderly patients in comparison with etiologies of chronic cough observed in non-elderly patients. METHODS: From 2,989 new patients presenting consecutively to the Department of Respiratory Medicine of the Tongji Hospital over a 1.5-year period, 287 patients with chronic cough were enrolled in the study. Patients aged > or =60 years were assigned to the elderly group. The elderly group comprised 104 patients and the non-elderly group the remaining 183 patients. The causes of cough were primarily evaluated according to a modification of Irwin's anatomic diagnostic protocol which included induced sputum cytology, verified by the specific therapy. RESULTS: Cough-variant asthma (34.6 vs. 41.5%) and upper airway cough syndrome (19.3 vs. 23.5%) were the most common causes of chronic cough both in the elderly and non-elderly groups. The distribution of causes and frequency were significantly different between elderly and non-elderly groups: angiotensin-converting enzyme inhibitor (ACEI)-induced cough (16.3 vs. 1.7%, chi(2) value = 22.12, p < 0.001) and gastroesophageal reflux disease (GERD; 10.6 vs. 3.7%, chi(2) value = 5.14, p = 0.02) were more common in the elderly group. CONCLUSIONS: A more frequent incidence of ACEI-induced cough and GERD is the distinctive feature in the cause distribution between elderly and non-elderly patients with chronic cough. Copyright 2008 S. Karger AG, Basel.
BACKGROUND: The causes of chronic cough in elderly patients have not been specifically investigated. Therefore, it remains to be determined whether chronic cough differs between elderly and non-elderly patients. OBJECTIVES: To investigate the distribution of causes of chronic cough in elderly patients in comparison with etiologies of chronic cough observed in non-elderly patients. METHODS: From 2,989 new patients presenting consecutively to the Department of Respiratory Medicine of the Tongji Hospital over a 1.5-year period, 287 patients with chronic cough were enrolled in the study. Patients aged > or =60 years were assigned to the elderly group. The elderly group comprised 104 patients and the non-elderly group the remaining 183 patients. The causes of cough were primarily evaluated according to a modification of Irwin's anatomic diagnostic protocol which included induced sputum cytology, verified by the specific therapy. RESULTS:Cough-variant asthma (34.6 vs. 41.5%) and upper airway cough syndrome (19.3 vs. 23.5%) were the most common causes of chronic cough both in the elderly and non-elderly groups. The distribution of causes and frequency were significantly different between elderly and non-elderly groups: angiotensin-converting enzyme inhibitor (ACEI)-induced cough (16.3 vs. 1.7%, chi(2) value = 22.12, p < 0.001) and gastroesophageal reflux disease (GERD; 10.6 vs. 3.7%, chi(2) value = 5.14, p = 0.02) were more common in the elderly group. CONCLUSIONS: A more frequent incidence of ACEI-induced cough and GERD is the distinctive feature in the cause distribution between elderly and non-elderly patients with chronic cough. Copyright 2008 S. Karger AG, Basel.
Authors: Cynthia T French; Rebecca L Diekemper; Richard S Irwin; Todd M Adams; Kenneth W Altman; Alan F Barker; Surinder S Birring; Fiona Blackhall; Donald C Bolser; Louis-Philippe Boulet; Sidney S Braman; Christopher Brightling; Priscilla Callahan-Lyon; Brendan J Canning; Anne B Chang; Remy Coeytaux; Terrie Cowley; Paul Davenport; Rebecca L Diekemper; Satoru Ebihara; Ali A El Solh; Patricio Escalante; Anthony Feinstein; Stephen K Field; Dina Fisher; Cynthia T French; Peter Gibson; Philip Gold; Michael K Gould; Cameron Grant; Susan M Harding; Anthony Harnden; Adam T Hill; Richard S Irwin; Peter J Kahrilas; Karina A Keogh; Andrew P Lane; Kaiser Lim; Mark A Malesker; Peter Mazzone; Stuart Mazzone; Douglas C McCrory; Lorcan McGarvey; Alex Molasiotis; M Hassan Murad; Peter Newcombe; Huong Q Nguyen; John Oppenheimer; David Prezant; Tamara Pringsheim; Marcos I Restrepo; Mark Rosen; Bruce Rubin; Jay H Ryu; Jaclyn Smith; Susan M Tarlo; Anne E Vertigan; Gang Wang; Miles Weinberger; Kelly Weir Journal: Chest Date: 2015-07 Impact factor: 9.410
Authors: Peter J Kahrilas; Kenneth W Altman; Anne B Chang; Stephen K Field; Susan M Harding; Andrew P Lane; Kaiser Lim; Lorcan McGarvey; Jaclyn Smith; Richard S Irwin Journal: Chest Date: 2016-09-07 Impact factor: 9.410