James A Ponto1. 1. College of Pharmacy, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. james-ponto@uiowa.edu
Abstract
OBJECTIVE: To review special safety considerations in the preparation of technetium 99m (Tc-99m) diethylenetriaminepentaacetic acid (DTPA; generic name, pentetate) for cerebrospinal fluid (CSF)-related imaging procedures. DATA SOURCES: Review of practices and results at one institution supplemented with findings and recommendations from the literature. Literature searches were conducted via Medline/PubMed using the following terms: Tc-99m DTPA/pentetate, CSF, cisternography, intrathecal, and adverse reactions. The author's own files were also searched for articles (e.g., in newsletters) not indexed by Medline/PubMed. STUDY SELECTION: Articles considered appropriate for review included all human research studies, reviews, case reports, abstracts, and letters published in English on Tc-99m DTPA use in CSF-related imaging procedures, especially with regard to safety or adverse reactions. DATA EXTRACTION: All information related to safety precautions and adverse reactions associated with Tc-99m DTPA injected intrathecally or otherwise used for CSF-related imaging procedures were considered. DATA SYNTHESIS: 18 years' experience in one institution was reviewed with the added perspective of literature findings and recommendations. CONCLUSION: With proper attention to safety considerations, Tc-99m DTPA can be safely used in CSF-related imaging procedures.
OBJECTIVE: To review special safety considerations in the preparation of technetium 99m (Tc-99m) diethylenetriaminepentaacetic acid (DTPA; generic name, pentetate) for cerebrospinal fluid (CSF)-related imaging procedures. DATA SOURCES: Review of practices and results at one institution supplemented with findings and recommendations from the literature. Literature searches were conducted via Medline/PubMed using the following terms: Tc-99mDTPA/pentetate, CSF, cisternography, intrathecal, and adverse reactions. The author's own files were also searched for articles (e.g., in newsletters) not indexed by Medline/PubMed. STUDY SELECTION: Articles considered appropriate for review included all human research studies, reviews, case reports, abstracts, and letters published in English on Tc-99mDTPA use in CSF-related imaging procedures, especially with regard to safety or adverse reactions. DATA EXTRACTION: All information related to safety precautions and adverse reactions associated with Tc-99mDTPA injected intrathecally or otherwise used for CSF-related imaging procedures were considered. DATA SYNTHESIS: 18 years' experience in one institution was reviewed with the added perspective of literature findings and recommendations. CONCLUSION: With proper attention to safety considerations, Tc-99mDTPA can be safely used in CSF-related imaging procedures.