Literature DB >> 18595690

4-Hydroxy-5-pyrrolinone-3-carboxamide HIV-1 integrase inhibitors.

Paola Pace1, Stéphane A H Spieser, Vincenzo Summa.   

Abstract

The viral enzyme integrase is essential for the replication of HIV-1 and, after the discovery of Isentress, represents a validated target for anti-retroviral therapy. Incorporation of the dihydroxycarbonyl pharmacophore into a pyrrolinone scaffold led to the discovery of 5-pyrrolinone-3-carboxamides as a structurally diverse class of HIV-1 integrase inhibitors.

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Year:  2008        PMID： 18595690     DOI： 10.1016/j.bmcl.2008.06.056

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

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2.  Stereoselective Synthesis of Quaternary Pyrrolidine-2,3-diones and β-Amino Acids.

Authors:  Nataliia V Shymanska; Joshua G Pierce
Journal:  Org Lett       Date:  2017-05-24       Impact factor: 6.005

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Journal:  Bioorg Med Chem       Date:  2012-03-01       Impact factor: 3.641

4.  N-tert-Butyl-2-{2-[2-(4-chloro-phen-yl)-4-hy-droxy-1-(5-methyl-isoxazol-3-yl)-5-oxo-2,5-di-hydro-1H-pyrrol-3-yl]-N-(4-meth-oxy-phen-yl)acetamido}-2-(4-meth-oxy-phen-yl)acetamide methanol monosolvate: single-crystal X-ray diffraction study and Hirshfeld surface analysis.

Authors:  Mariia O Shyshkina; Yana I Sakhno; Oleksandr V Radchenko; Svitlana V Shishkina; Sergey M Desenko; Valentyn A Chebanov
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2021-11-02

5.  Multicomponent Synthesis of Unsaturated γ-Lactam Derivatives. Applications as Antiproliferative Agents through the Bioisosterism Approach: Carbonyl vs. Phosphoryl Group.

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Journal:  Pharmaceuticals (Basel)       Date:  2022-04-22

6.  Aldol reactions in multicomponent reaction based domino pathways: a multipurpose enabling tool in heterocyclic chemistry.

Authors:  Zhigang Xu; Fabio De Moliner; Alexandra P Cappelli; Christopher Hulme
Journal:  Org Lett       Date:  2013-05-29       Impact factor: 6.005

7.  Total synthesis of leopolic acid A, a natural 2,3-pyrrolidinedione with antimicrobial activity.

Authors:  Atul A Dhavan; Rahul D Kaduskar; Loana Musso; Leonardo Scaglioni; Piera Anna Martino; Sabrina Dallavalle
Journal:  Beilstein J Org Chem       Date:  2016-07-29       Impact factor: 2.883

8.  Synthesis of a leopolic acid-inspired tetramic acid with antimicrobial activity against multidrug-resistant bacteria.

Authors:  Luce Mattio; Loana Musso; Leonardo Scaglioni; Andrea Pinto; Piera Anna Martino; Sabrina Dallavalle
Journal:  Beilstein J Org Chem       Date:  2018-09-24       Impact factor: 2.883
  8 in total

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