Literature DB >> 18595689

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition.

Mark E Schnute1, Roger J Brideau, Sarah A Collier, Michele M Cudahy, Todd A Hopkins, Mary L Knechtel, Nancee L Oien, Robert S Sackett, Allen Scott, Mari L Stephan, Michael W Wathen, Janet L Wieber.   

Abstract

A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.

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Year:  2008        PMID： 18595689     DOI： 10.1016/j.bmcl.2008.06.060

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Furoates and thenoates inhibit pyruvate dehydrogenase kinase 2 allosterically by binding to its pyruvate regulatory site.

Authors:  Tiziana Masini; Barbara Birkaya; Simon van Dijk; Milon Mondal; Johan Hekelaar; Manuel Jäger; Anke C Terwisscha van Scheltinga; Mulchand S Patel; Anna K H Hirsch; Edelmiro Moman
Journal:  J Enzyme Inhib Med Chem       Date:  2016-07-19       Impact factor: 5.051

2.  Iridium-Catalyzed Silylation of Five-Membered Heteroarenes: High Sterically Derived Selectivity from a Pyridyl-Imidazoline Ligand.

Authors:  Caleb Karmel; Camille Z Rubel; Elena V Kharitonova; John F Hartwig
Journal:  Angew Chem Weinheim Bergstr Ger       Date:  2020-01-22

3.  Synthesis and anti-HCMV activity of 1-[ω-(phenoxy)alkyl]uracil derivatives and analogues thereof.

Authors:  Mikhail S Novikov; Denis A Babkov; Maria P Paramonova; Anastasia L Khandazhinskaya; Alexander A Ozerov; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Jan Balzarini; Katherine L Seley-Radtke
Journal:  Bioorg Med Chem       Date:  2013-05-16       Impact factor: 3.641

4.  Toward the discovery of dual HCMV-VZV inhibitors: Synthesis, structure activity relationship analysis, and cytotoxicity studies of long chained 2-uracil-3-yl-N-(4-phenoxyphenyl)acetamides.

Authors:  Denis A Babkov; Anastasia L Khandazhinskaya; Alexander O Chizhov; Graciela Andrei; Robert Snoeck; Katherine L Seley-Radtke; Mikhail S Novikov
Journal:  Bioorg Med Chem       Date:  2015-09-21       Impact factor: 3.641
  4 in total

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