STUDY OBJECTIVES: We investigated the prevalence of silent cerebrovascular lesions in patients with obstructive sleep apnea (OSA) and the correlation between OSA severity and prevalence of silent cerebrovascular lesions in Japanese patients. METHODS: Study subjects were 192 polysomnography (PSG)-confirmed patients who visited the sleep disorders clinic in our university hospital. None had a history of cerebrovascular disease (CVD). We performed a cross-sectional study on OSA severity and the prevalence of silent cerebrovascular lesions detected by brain MRI analysis. RESULTS: The control (AHI < 5/h) group included 19 subjects with a mean AHI of 1.7 +/- 1.6/h, the mild OSAS (AHI 5 to < 15/h) group included 25 patients with a mean AHI of 9.5 +/- 3.7/h, the moderate OSAS (AHI 15 to < 30/h) group included 35 patients with a mean AHI of 22.0 +/- 7.0/h while the severe OSAS (AHI > or = 30/h) group included 113 patients with a mean AHI of 59.9 +/- 20.5/h. A larger percentage of patients with severe OSAS had a higher BMI and hyperglycemia than those with mild or moderate OSAS and control subjects (p < 0.05). Silent lacunar infarction was identified in 4 (21.1%) control subjects, 3 (12.0%) patients with mild OSA, 17 (48.6%) with moderate OSA and 61 (54.0%) with severe OSA. Among control subjects and the mild, moderate, and severe OSA groups, 4 (21.1%), 5 (20.0%), 19 (54.3%) and 61(54.0%), respectively, had periventricular hyperintensity (PVH); most PVH was mild to moderate. CONCLUSION: Results indicate that patients with moderate to severe (AHI > or = 15/h) OSA have a higher prevalence of silent cerebrovascular lesion than those with less severe OSA.
STUDY OBJECTIVES: We investigated the prevalence of silent cerebrovascular lesions in patients with obstructive sleep apnea (OSA) and the correlation between OSA severity and prevalence of silent cerebrovascular lesions in Japanese patients. METHODS: Study subjects were 192 polysomnography (PSG)-confirmed patients who visited the sleep disorders clinic in our university hospital. None had a history of cerebrovascular disease (CVD). We performed a cross-sectional study on OSA severity and the prevalence of silent cerebrovascular lesions detected by brain MRI analysis. RESULTS: The control (AHI < 5/h) group included 19 subjects with a mean AHI of 1.7 +/- 1.6/h, the mild OSAS (AHI 5 to < 15/h) group included 25 patients with a mean AHI of 9.5 +/- 3.7/h, the moderate OSAS (AHI 15 to < 30/h) group included 35 patients with a mean AHI of 22.0 +/- 7.0/h while the severe OSAS (AHI > or = 30/h) group included 113 patients with a mean AHI of 59.9 +/- 20.5/h. A larger percentage of patients with severe OSAS had a higher BMI and hyperglycemia than those with mild or moderate OSAS and control subjects (p < 0.05). Silent lacunar infarction was identified in 4 (21.1%) control subjects, 3 (12.0%) patients with mild OSA, 17 (48.6%) with moderate OSA and 61 (54.0%) with severe OSA. Among control subjects and the mild, moderate, and severe OSA groups, 4 (21.1%), 5 (20.0%), 19 (54.3%) and 61(54.0%), respectively, had periventricular hyperintensity (PVH); most PVH was mild to moderate. CONCLUSION: Results indicate that patients with moderate to severe (AHI > or = 15/h) OSA have a higher prevalence of silent cerebrovascular lesion than those with less severe OSA.
Authors: T Hori; Y Sugita; E Koga; S Shirakawa; K Inoue; S Uchida; H Kuwahara; M Kousaka; T Kobayashi; Y Tsuji; M Terashima; K Fukuda; N Fukuda Journal: Psychiatry Clin Neurosci Date: 2001-06 Impact factor: 5.188
Authors: Abu S M Shamsuzzaman; Mikolaj Winnicki; Paola Lanfranchi; Robert Wolk; Tomas Kara; Valentina Accurso; Virend K Somers Journal: Circulation Date: 2002-05-28 Impact factor: 29.690
Authors: Kristi Reynolds; Brian Lewis; John David L Nolen; Gregory L Kinney; Bhavani Sathya; Jiang He; Brian L Lewis Journal: JAMA Date: 2003-02-05 Impact factor: 56.272
Authors: John Robbins; Susan Redline; Ann Ervin; Joyce A Walsleben; Jingzhong Ding; F Javier Nieto Journal: J Clin Sleep Med Date: 2005-04-15 Impact factor: 4.062