Literature DB >> 1859425

Interleukin-4 blocks parathyroid hormone-related protein-induced hypercalcemia in vivo.

K Nagasaki1, K Yamaguchi, K Watanabe, S Eto, K Abe.   

Abstract

Interleukin (IL)-4 inhibits bone resorption. In the present study, the effect of IL-4 on hypercalcemia in nude mice under two experimental conditions was assessed. IL-4 inhibited plasma calcium elevation induced by parathyroid hormone-related protein (PTHrP) infusion. In hypercalcemic nude mice bearing PTHrP-producing tumors, IL-4 lowered plasma calcium levels to almost the normal range. These results indicate that IL-4 blocks PTHrP-induced hypercalcemia in vivo.

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Year:  1991        PMID： 1859425     DOI： 10.1016/0006-291x(91)90163-2

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  3 in total

1.  Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts.

Authors:  Atsushi Yamada; Masamichi Takami; Tadaharu Kawawa; Rika Yasuhara; Baohong Zhao; Ayako Mochizuki; Yoichi Miyamoto; Tomoo Eto; Hisataka Yasuda; Yuko Nakamichi; Nacksung Kim; Takenobu Katagiri; Tatsuo Suda; Ryutaro Kamijo
Journal:  Immunology       Date:  2007-04       Impact factor: 7.397

2.  Cinacalcet for hypercalcemia caused by pulmonary squamous cell carcinoma producing parathyroid hormone-related Peptide.

Authors:  Anneke Bech; Koen Smolders; Darryl Telting; Hans de Boer
Journal:  Case Rep Oncol       Date:  2012-01-07

Review 3.  Animal Models of Cancer-Associated Hypercalcemia.

Authors:  Nicole A Kohart; Said M Elshafae; Justin T Breitbach; Thomas J Rosol
Journal:  Vet Sci       Date:  2017-04-13
  3 in total

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