Literature DB >> 18593875

PERspective on PER phosphorylation.

Justin Blau1.   

Abstract

Period (PER) proteins are essential parts of the molecular clocks that control circadian rhythms in flies and mammals. Phosphorylation regulates PER's stability and subcellular localization; however, the physiologically relevant sites have been difficult to identify in spite of knowing the relevant kinase. In this issue of Genes & Development, Chiu and colleagues (1758-1772) identify a key phosphorylation site on PER that recruits the F-box protein Slimb to trigger PER degradation and set clock speed.

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Year:  2008        PMID： 18593875      PMCID： PMC2732424          DOI： 10.1101/gad.1696408

Source DB:  PubMed          Journal:  Genes Dev        ISSN： 0890-9369            Impact factor:   11.361


  27 in total

1.  Role of molecular oscillations in generating behavioral rhythms in Drosophila.

Authors:  Z Yang; A Sehgal
Journal:  Neuron       Date:  2001-02       Impact factor: 17.173

2.  PER-TIM interactions in living Drosophila cells: an interval timer for the circadian clock.

Authors:  Pablo Meyer; Lino Saez; Michael W Young
Journal:  Science       Date:  2006-01-13       Impact factor: 47.728

3.  Phosphorylation of period is influenced by cycling physical associations of double-time, period, and timeless in the Drosophila clock.

Authors:  B Kloss; A Rothenfluh; M W Young; L Saez
Journal:  Neuron       Date:  2001-06       Impact factor: 17.173

4.  An opposite role for tau in circadian rhythms revealed by mathematical modeling.

Authors:  Monica Gallego; Erik J Eide; Margaret F Woolf; David M Virshup; Daniel B Forger
Journal:  Proc Natl Acad Sci U S A       Date:  2006-07-03       Impact factor: 11.205

5.  An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.

Authors:  K L Toh; C R Jones; Y He; E J Eide; W A Hinz; D M Virshup; L J Ptácek; Y H Fu
Journal:  Science       Date:  2001-02-09       Impact factor: 47.728

6.  The F-box protein slimb controls the levels of clock proteins period and timeless.

Authors:  Brigitte Grima; Annie Lamouroux; Elisabeth Chélot; Christian Papin; Bernadette Limbourg-Bouchon; François Rouyer
Journal:  Nature       Date:  2002-11-14       Impact factor: 49.962

7.  Short-period mutations of per affect a double-time-dependent step in the Drosophila circadian clock.

Authors:  A Rothenfluh; M Abodeely; M W Young
Journal:  Curr Biol       Date:  2000-11-02       Impact factor: 10.834

8.  In vivo circadian function of casein kinase 2 phosphorylation sites in Drosophila PERIOD.

Authors:  Jui-Ming Lin; Analyne Schroeder; Ravi Allada
Journal:  J Neurosci       Date:  2005-11-30       Impact factor: 6.167

9.  double-time is a novel Drosophila clock gene that regulates PERIOD protein accumulation.

Authors:  J L Price; J Blau; A Rothenfluh; M Abodeely; B Kloss; M W Young
Journal:  Cell       Date:  1998-07-10       Impact factor: 41.582

10.  The Drosophila clock gene double-time encodes a protein closely related to human casein kinase Iepsilon.

Authors:  B Kloss; J L Price; L Saez; J Blau; A Rothenfluh; C S Wesley; M W Young
Journal:  Cell       Date:  1998-07-10       Impact factor: 41.582
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  15 in total

1.  PRR5 regulates phosphorylation, nuclear import and subnuclear localization of TOC1 in the Arabidopsis circadian clock.

Authors:  Lei Wang; Sumire Fujiwara; David E Somers
Journal:  EMBO J       Date:  2010-04-20       Impact factor: 11.598

2.  Of switches and hourglasses: regulation of subcellular traffic in circadian clocks by phosphorylation.

Authors:  Ozgür Tataroğlu; Tobias Schafmeier
Journal:  EMBO Rep       Date:  2010-11-05       Impact factor: 8.807

3.  Circadian rhythms. Decoupling circadian clock protein turnover from circadian period determination.

Authors:  Luis F Larrondo; Consuelo Olivares-Yañez; Christopher L Baker; Jennifer J Loros; Jay C Dunlap
Journal:  Science       Date:  2015-01-30       Impact factor: 47.728

4.  Essential roles of CKIdelta and CKIepsilon in the mammalian circadian clock.

Authors:  Hyeongmin Lee; Rongmin Chen; Yongjin Lee; Seunghee Yoo; Choogon Lee
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-30       Impact factor: 11.205

5.  Casein kinase 1 delta regulates the pace of the mammalian circadian clock.

Authors:  Jean-Pierre Etchegaray; Kazuhiko K Machida; Elizabeth Noton; Cara M Constance; Robert Dallmann; Marianne N Di Napoli; Jason P DeBruyne; Christopher M Lambert; Elizabeth A Yu; Steven M Reppert; David R Weaver
Journal:  Mol Cell Biol       Date:  2009-05-04       Impact factor: 4.272

6.  Picrotoxin dramatically speeds the mammalian circadian clock independent of Cys-loop receptors.

Authors:  G Mark Freeman; Masato Nakajima; Hiroki R Ueda; Erik D Herzog
Journal:  J Neurophysiol       Date:  2013-04-10       Impact factor: 2.714

7.  TOC1 clock protein phosphorylation controls complex formation with NF-YB/C to repress hypocotyl growth.

Authors:  Jiapei Yan; Shibai Li; Yeon Jeong Kim; Qingning Zeng; Amandine Radziejwoski; Lei Wang; Yuko Nomura; Hirofumi Nakagami; David E Somers
Journal:  EMBO J       Date:  2021-11-02       Impact factor: 11.598

Review 8.  AMP-activated protein kinase as a key molecular link between metabolism and clockwork.

Authors:  Yongjin Lee; Eun-Kyoung Kim
Journal:  Exp Mol Med       Date:  2013-07-26       Impact factor: 8.718

Review 9.  The implications of multiple circadian clock origins.

Authors:  Michael Rosbash
Journal:  PLoS Biol       Date:  2009-03-17       Impact factor: 8.029

10.  PER3 polymorphism and cardiac autonomic control: effects of sleep debt and circadian phase.

Authors:  Antoine U Viola; Lynette M James; Simon N Archer; Derk-Jan Dijk
Journal:  Am J Physiol Heart Circ Physiol       Date:  2008-10-03       Impact factor: 4.733
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