| Literature DB >> 18593612 |
Irina Orlovskaya1, Ingrid Schraufstatter, Jeanne Loring, Sophia Khaldoyanidi.
Abstract
This review is focused on methods that are used to derive hematopoietic cells from embryonic stem cells (ESCs). One of the strategies that have been recently used to achieve this goal is an approach of mimicking the hematopoietic niche in vitro by using hematopoiesis-supportive feeder cells, cocktails of soluble hematopoietic growth factors and a variety of matrices. While there is clear evidence that it is possible to derive hematopoietic stem cells (HSCs) and subsequently committed hematopoietic progenitors and mature cells from ESCs, there remains the need to address multiple issues including the efficiency of HSCs derivation in vitro and their proper functionality.Mesh:
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Year: 2008 PMID: 18593612 DOI: 10.1016/j.ymeth.2008.03.002
Source DB: PubMed Journal: Methods ISSN: 1046-2023 Impact factor: 3.608