Literature DB >> 18593586

Role of TAp73alpha in induction of apoptosis by transforming growth factor-beta in gastric cancer cells.

Yasuko Yamamura1, Wei Lin Lee, Mei Xian Goh, Yoshiaki Ito.   

Abstract

Transforming growth factor-beta (TGF-beta) is implicated as a tumor suppressor because it eliminates cancer cells from normal tissues by inhibiting cell growth and inducing apoptosis. Although p53 tumor suppressor is required for TGF-beta-induced p21 WAF1 expression and cell growth inhibition, its role in TGF-beta-induced apoptosis remains unclear. Here, we report that TAp73alpha, which is a member of the p53 family, binds to p53-binding sites in the promoters of proapoptotic Bax and Puma to activate their transcription, and mediates TGF-beta-induced apoptosis in gastric cancer cells. Our findings reveal a novel role of TAp73alpha in the induction of apoptosis by TGF-beta in cancer cells.

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Year:  2008        PMID： 18593586     DOI： 10.1016/j.febslet.2008.06.046

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  5 in total

1.  Overexpression of the ∆Np73 isoform is associated with centrosome amplification in brain tumor cell lines.

Authors:  Erika Mikulenkova; Jakub Neradil; Karel Zitterbart; Jaroslav Sterba; Renata Veselska
Journal:  Tumour Biol       Date:  2015-04-25

Review 2.  A balancing act: orchestrating amino-truncated and full-length p73 variants as decisive factors in cancer progression.

Authors:  D Engelmann; C Meier; V Alla; B M Pützer
Journal:  Oncogene       Date:  2014-11-10       Impact factor: 9.867

Review 3.  The p53 circuit board.

Authors:  Kelly D Sullivan; Corrie L Gallant-Behm; Ryan E Henry; Jean-Luc Fraikin; Joaquín M Espinosa
Journal:  Biochim Biophys Acta       Date:  2012-02-07

4.  Quercetin enhances the effects of 5-fluorouracil-mediated growth inhibition and apoptosis of esophageal cancer cells by inhibiting NF-κB.

Authors:  Lu Chuang-Xin; Wang Wen-Yu; Cui Yao; Li Xiao-Yan; Zhou Yun
Journal:  Oncol Lett       Date:  2012-07-27       Impact factor: 2.967

5.  Transforming growth factor-β directly induces p53-up-regulated modulator of apoptosis (PUMA) during the rapid induction of apoptosis in myc-driven B-cell lymphomas.

Authors:  Lindsay C Spender; Matthew J Carter; Darren I O'Brien; Louise J Clark; Jian Yu; Ewa M Michalak; Lina Happo; Mark S Cragg; Gareth J Inman
Journal:  J Biol Chem       Date:  2012-12-14       Impact factor: 5.157
  5 in total

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