Literature DB >> 18593527

Modeled structure of trypanothione reductase of Leishmania infantum.

Bishal K Singh1, Nandini Sarkar, M V Jagannadham, Vikash K Dubey.   

Abstract

Trypanothione reductase is an important target enzyme for structure-based drug design against Leishmania. We used homology modeling to construct a three-dimensional structure of the trypanothione reductase (TR) of Leishmania infantum. The structure shows acceptable Ramachandran statistics and a remarkably different active site from glutathione reductase(GR). Thus, a specific inhibitor against TR can be designed without interfering with host (human) GR activity.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18593527     DOI： 10.5483/bmbrep.2008.41.6.444

Source DB:  PubMed          Journal:  BMB Rep        ISSN： 1976-6696            Impact factor:   4.778


  9 in total

1.  Evaluation of selected antitumor agents as subversive substrate and potential inhibitor of trypanothione reductase: an alternative approach for chemotherapy of Leishmaniasis.

Authors:  Anil Kumar Shukla; Sanjukta Patra; Vikash Kumar Dubey
Journal:  Mol Cell Biochem       Date:  2011-02-26       Impact factor: 3.396

2.  Evaluation of plumbagin and its derivative as potential modulators of redox thiol metabolism of Leishmania parasite.

Authors:  Neha Sharma; Anil Kumar Shukla; Mousumi Das; Vikash Kumar Dubey
Journal:  Parasitol Res       Date:  2011-06-30       Impact factor: 2.289

3.  In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches.

Authors:  Lina S Prieto Cárdenas; Karen A Arias Soler; Diana L Nossa González; Wilson E Rozo Núñez; Agobardo Cárdenas-Chaparro; Pablo R Duchowicz; Jovanny A Gómez Castaño
Journal:  Pharmaceuticals (Basel)       Date:  2022-05-31

4.  Anti-Trypanosoma cruzi and anti-leishmanial activity by quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives.

Authors:  Juan Carlos Villalobos-Rocha; Luvia Sánchez-Torres; Benjamín Nogueda-Torres; Aldo Segura-Cabrera; Carlos A García-Pérez; Virgilio Bocanegra-García; Isidro Palos; Antonio Monge; Gildardo Rivera
Journal:  Parasitol Res       Date:  2014-04-02       Impact factor: 2.289

5.  Vitamin C and Vitamin D3 show strong binding with the amyloidogenic region of G555F mutant of Fibrinogen A alpha-chain associated with renal amyloidosis: proposed possible therapeutic intervention.

Authors:  Monu Pande; Debanjan Kundu; Ragini Srivastava
Journal:  Mol Divers       Date:  2021-03-12       Impact factor: 2.943

6.  Footprinting of inhibitor interactions of in silico identified inhibitors of trypanothione reductase of Leishmania parasite.

Authors:  Santhosh K Venkatesan; Vikash Kumar Dubey
Journal:  ScientificWorldJournal       Date:  2012-04-01

Review 7.  Fresh insights into the pyrimidine metabolism in the trypanosomatids.

Authors:  Kartikeya Tiwari; Vikash Kumar Dubey
Journal:  Parasit Vectors       Date:  2018-02-08       Impact factor: 3.876

8.  Quantitative Proteome Analysis of Leishmania donovani under Spermidine Starvation.

Authors:  Shalini Singh; Vikash Kumar Dubey
Journal:  PLoS One       Date:  2016-04-28       Impact factor: 3.240

9.  Dataset generated for Dissection of mechanisms of Trypanothione Reductase and Tryparedoxin Peroxidase through dynamic network analysis and simulations in leishmaniasis.

Authors:  Anurag Kumar; Bhaskar Saha; Shailza Singh
Journal:  Data Brief       Date:  2017-10-19
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.