Inverse independent component analysis facilitates clarification of the accessory conductive pathway of Wolf-Parkinson-White syndrome electrocardiogram.

Our aim was to demonstrate a digital analyzing method that could extract the potential of early excitation derived from accessory conductive pathway (ACP) from fusion of the QRS complex wave of the electrocardiogram of Wolf-Parkinson-White (WPW) syndrome. A 13-year-old boy with WPW syndrome received successful catheter ablation therapy. ECG was recorded and analyzed using independent component analysis (ICA) and inverse independent component analysis (I-ICA), at pretherapy and posttherapy. We identified the ACP potential and the following potential spread to the ventricle. Results agreed with those of intracardiac mapping, locating the ACP in the left posterior side of the heart. ICA and I-ICA might be useful for noninvasive analysis of WPW syndrome ECG and other electrocardiac abnormalities.