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Literature DB >> 18591820

Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.

Miao-Miao Jiang¹, Yi Dai, Hao Gao, Xue Zhang, Guang-Hui Wang, Jia-You He, Qiong-Ying Hu, Jin-Zhang Zeng, Xiao-Kun Zhang, Xin-Sheng Yao.

Abstract

Toxicarioside D (1), a new cardenolide, along with 10 other known ones, was isolated from the stem of Antiaris toxicaria LESCH. by bioassay-guided fractionation. Their structures were determined on the basis of spectroscopic analysis. All the reported compounds effectively inhibited the growth of various cancer cell lines at nanomolar concentrations. Inhibition of cancer cell growth was accompanied with induction of the expression of Nur77, a potent apoptotic member of the steroid/thyroid hormone receptor superfamily.

Entities: Chemical Disease Species

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Year: 2008 PMID： 18591820 DOI： 10.1248/cpb.56.1005

Source DB: PubMed Journal: Chem Pharm Bull (Tokyo) ISSN： 0009-2363 Impact factor: 1.645

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Cited

7 in total

1. Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation.

Authors: Hem Raj Khatri; Bijay Bhattarai; Will Kaplan; Zhongzheng Li; Marcus John Curtis Long; Yimon Aye; Pavel Nagorny
Journal: J Am Chem Soc Date: 2019-03-14 Impact factor: 15.419

2. Regioselective single pot C3-glycosylation of strophanthidol using methylboronic acid as a transient protecting group.

Authors: Jia-Hui Tay; Valentin Dorokhov; Sibin Wang; Pavel Nagorny
Journal: J Antibiot (Tokyo) Date: 2019-04-04 Impact factor: 2.649

3. Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-κB/bFGF signaling.

Authors: Jun-Li Guo; Shao-Jiang Zheng; Yue-Nan Li; Wei Jie; Xin-Bao Hao; Tian-Fa Li; Li-Ping Xia; Wen-Li Mei; Feng-Ying Huang; Yue-Qiong Kong; Qi-Yi He; Kun Yang; Guang-Hong Tan; Hao-Fu Dai
Journal: World J Gastroenterol Date: 2012-04-14 Impact factor: 5.742

4. Enantioselective Total Synthesis of Cannogenol-3-O-α-l-rhamnoside via Sequential Cu(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions.

Authors: Bijay Bhattarai; Pavel Nagorny
Journal: Org Lett Date: 2017-12-15 Impact factor: 6.005

Cardenolides from Antiaris toxicaria as potent selective Nur77 modulators.

1. Modular Total Synthesis and Cell-Based Anticancer Activity Evaluation of Ouabagenin and Other Cardiotonic Steroids with Varying Degrees of Oxygenation.

2. Regioselective single pot C3-glycosylation of strophanthidol using methylboronic acid as a transient protecting group.

3. Toxicarioside A inhibits SGC-7901 proliferation, migration and invasion via NF-κB/bFGF signaling.

4. Enantioselective Total Synthesis of Cannogenol-3-O-α-l-rhamnoside via Sequential Cu(II)-Catalyzed Michael Addition/Intramolecular Aldol Cyclization Reactions.

5. Inhibition of β-catenin signaling by nongenomic action of orphan nuclear receptor Nur77.

6. Toxicarioside A inhibits tumor growth and angiogenesis: involvement of TGF-β/endoglin signaling.

7. A new cytotoxic 19-nor-cardenolide from the latex of Antiaris toxicaria.