Literature DB >> 18591262

Antifungal resistance of Candida glabrata vaginal isolates and development of a quantitative reverse transcription-PCR-based azole susceptibility assay.

Scott E Gygax1, John-Paul Vermitsky, Sean G Chadwick, Matthew J Self, Jessica A Zimmerman, Eli Mordechai, Martin E Adelson, Jason P Trama.   

Abstract

A multiplex quantitative reverse transcription-PCR assay was developed to detect azole resistance in Candida glabrata, an important opportunistic pathogen that develops resistance rapidly. Resistance was defined as a >or=3-fold increase in CDR1 expression by this assay, which proved to be 100% sensitive and 95% specific in comparison to the gold standard broth microdilution assay.

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Year:  2008        PMID： 18591262      PMCID： PMC2533493          DOI： 10.1128/AAC.00462-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

1.  Prevalence of Candida glabrata and its response to boric acid vaginal suppositories in comparison with oral fluconazole in patients with diabetes and vulvovaginal candidiasis.

Authors:  Debarti Ray; Ravinder Goswami; Uma Banerjee; Vatsla Dadhwal; Deepti Goswami; Piyali Mandal; Vishnubhatla Sreenivas; Narayana Kochupillai
Journal:  Diabetes Care       Date:  2007-02       Impact factor: 19.112

2.  The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents.

Authors:  D Sanglard; F Ischer; D Calabrese; P A Majcherczyk; J Bille
Journal:  Antimicrob Agents Chemother       Date:  1999-11       Impact factor: 5.191

3.  The epidemiology of candidemia in two United States cities: results of a population-based active surveillance.

Authors:  A S Kao; M E Brandt; W R Pruitt; L A Conn; B A Perkins; D S Stephens; W S Baughman; A L Reingold; G A Rothrock; M A Pfaller; R W Pinner; R A Hajjeh
Journal:  Clin Infect Dis       Date:  1999-11       Impact factor: 9.079

4.  Prospective epidemiologic analysis of triazole-resistant nosocomial Candida glabrata isolated from patients at a comprehensive cancer center.

Authors:  Amar Safdar; Donald Armstrong; Emily W Cross; David S Perlin
Journal:  Int J Infect Dis       Date:  2002-09       Impact factor: 3.623

5.  Trends in antifungal use and epidemiology of nosocomial yeast infections in a university hospital.

Authors:  Y F Berrouane; L A Herwaldt; M A Pfaller
Journal:  J Clin Microbiol       Date:  1999-03       Impact factor: 5.948

6.  Azole resistance in Candida glabrata: coordinate upregulation of multidrug transporters and evidence for a Pdr1-like transcription factor.

Authors:  John-Paul Vermitsky; Thomas D Edlind
Journal:  Antimicrob Agents Chemother       Date:  2004-10       Impact factor: 5.191

7.  Secular trends in nosocomial primary bloodstream infections in the United States, 1980-1989. National Nosocomial Infections Surveillance System.

Authors:  S N Banerjee; T G Emori; D H Culver; R P Gaynes; W R Jarvis; T Horan; J R Edwards; J Tolson; T Henderson; W J Martone
Journal:  Am J Med       Date:  1991-09-16       Impact factor: 4.965

8.  Antifungal susceptibility survey of 2,000 bloodstream Candida isolates in the United States.

Authors:  Luis Ostrosky-Zeichner; John H Rex; Peter G Pappas; Richard J Hamill; Robert A Larsen; Harold W Horowitz; William G Powderly; Newton Hyslop; Carol A Kauffman; John Cleary; Julie E Mangino; Jeannette Lee
Journal:  Antimicrob Agents Chemother       Date:  2003-10       Impact factor: 5.191

9.  Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study.

Authors:  Hilmar Wisplinghoff; Tammy Bischoff; Sandra M Tallent; Harald Seifert; Richard P Wenzel; Michael B Edmond
Journal:  Clin Infect Dis       Date:  2004-07-15       Impact factor: 9.079

10.  Fluconazole resistance associated with drug efflux and increased transcription of a drug transporter gene, PDH1, in Candida glabrata.

Authors:  H Miyazaki; Y Miyazaki; A Geber; T Parkinson; C Hitchcock; D J Falconer; D J Ward; K Marsden; J E Bennett
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191
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  9 in total

Review 1.  Molecular and nonmolecular diagnostic methods for invasive fungal infections.

Authors:  Marios Arvanitis; Theodora Anagnostou; Beth Burgwyn Fuchs; Angela M Caliendo; Eleftherios Mylonakis
Journal:  Clin Microbiol Rev       Date:  2014-07       Impact factor: 26.132

2.  UPC2A is required for high-level azole antifungal resistance in Candida glabrata.

Authors:  Sarah G Whaley; Kelly E Caudle; John-Paul Vermitsky; Sean G Chadwick; Geoffrey Toner; Katherine S Barker; Scott E Gygax; P David Rogers
Journal:  Antimicrob Agents Chemother       Date:  2014-05-27       Impact factor: 5.191

3.  Relative Contribution of the ABC Transporters Cdr1, Pdh1, and Snq2 to Azole Resistance in Candida glabrata.

Authors:  Sarah G Whaley; Qing Zhang; Kelly E Caudle; P David Rogers
Journal:  Antimicrob Agents Chemother       Date:  2018-09-24       Impact factor: 5.191

Review 4.  Antifungal drug resistance: do molecular methods provide a way forward?

Authors:  David S Perlin
Journal:  Curr Opin Infect Dis       Date:  2009-12       Impact factor: 4.915

5.  Flucytosine antagonism of azole activity versus Candida glabrata: role of transcription factor Pdr1 and multidrug transporter Cdr1.

Authors:  Zoë Steier; John-Paul Vermitsky; Geoffrey Toner; Scott E Gygax; Thomas Edlind; Santosh Katiyar
Journal:  Antimicrob Agents Chemother       Date:  2013-08-26       Impact factor: 5.191

Review 6.  Recent trends in molecular diagnostics of yeast infections: from PCR to NGS.

Authors:  Toni Gabaldón
Journal:  FEMS Microbiol Rev       Date:  2019-09-01       Impact factor: 16.408

7.  Vulvovaginal candidiasis and current perspectives: new risk factors and laboratory diagnosis by using MALDI TOF for identifying species in primary infection and recurrence.

Authors:  Lívia Custódio Pereira; Amabel Fernandes Correia; Zita Dinis Lopes da Silva; Ceres Nunes de Resende; Fabiana Brandão; Rosane Mansan Almeida; Yanna Karla de Medeiros Nóbrega
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2021-03-13       Impact factor: 3.267

8.  Preliminary study on the inhibitory effect of seaweed Gracilaria verrucosa extract on biofilm formation of Candida albicans cultured from the saliva of a smoker.

Authors:  Zaki Mubarak; Adintya Humaira; Basri A Gani; Zainal A Muchlisin
Journal:  F1000Res       Date:  2018-05-31

9.  Gain of function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence.

Authors:  Sélène Ferrari; Françoise Ischer; David Calabrese; Brunella Posteraro; Maurizio Sanguinetti; Giovanni Fadda; Bettina Rohde; Christopher Bauser; Oliver Bader; Dominique Sanglard
Journal:  PLoS Pathog       Date:  2009-01-16       Impact factor: 6.823
  9 in total

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