Literature DB >> 18590964

Cinnamoyl- and hydroxycinnamoyl amides of glaucine and their antioxidative and antiviral activities.

Maya Spasova1, Stefan Philipov, L Nikolaeva-Glomb, A S Galabov, Ts Milkova.   

Abstract

The aporphine alkaloid glaucine has been converted into 3-aminomethylglaucine and its free amino group has been linked to cinnamic, ferulic, sinapic, o-, and p-coumaric acids. The antioxidative potential of the synthesized amides was studied against DPPH(*) test. All of the tested compounds demonstrated higher radical scavenging activity than glaucine and 3-aminomethylglaucine, and lower antioxidative effect than the free hydroxycinnamic acids. The newly synthesized compounds were tested in vitro for antiviral activity against viruses belonging to different taxonomic groups.

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Year:  2008        PMID： 18590964     DOI： 10.1016/j.bmc.2008.06.010

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  9 in total

1.  A tetramethylpyrazine piperazine derivate CXC137 prevents cell injury in SH-SY5Y cells and improves memory dysfunction of rats with vascular Dementia.

Authors:  Hao Zhang; Rong Sun; Xin-Yong Liu; Xiao-Ming Shi; Wen-Fang Wang; Lu-Gang Yu; Xiu-Li Guo
Journal:  Neurochem Res       Date:  2013-12-20       Impact factor: 3.996

2.  High-throughput screen of natural product libraries for hsp90 inhibitors.

Authors:  Jason Davenport; Maurie Balch; Lakshmi Galam; Antwan Girgis; Jessica Hall; Brian S J Blagg; Robert L Matts
Journal:  Biology (Basel)       Date:  2014-02-10

3.  Screening of the Pan-African natural product library identifies ixoratannin A-2 and boldine as novel HIV-1 inhibitors.

Authors:  Ian Tietjen; Fidele Ntie-Kang; Philip Mwimanzi; Pascal Amoa Onguéné; Margaret A Scull; Thomas Oyebode Idowu; Abiodun Oguntuga Ogundaini; Luc Mbaze Meva'a; Berhanu M Abegaz; Charles M Rice; Kerstin Andrae-Marobela; Mark A Brockman; Zabrina L Brumme; David Fedida
Journal:  PLoS One       Date:  2015-04-01       Impact factor: 3.240

Review 4.  Ferulic Acid From Plant Biomass: A Phytochemical With Promising Antiviral Properties.

Authors:  Io Antonopoulou; Eleftheria Sapountzaki; Ulrika Rova; Paul Christakopoulos
Journal:  Front Nutr       Date:  2022-02-07

5.  The Inhibitory Potential of Ferulic Acid Derivatives against the SARS-CoV-2 Main Protease: Molecular Docking, Molecular Dynamics, and ADMET Evaluation.

Authors:  Io Antonopoulou; Eleftheria Sapountzaki; Ulrika Rova; Paul Christakopoulos
Journal:  Biomedicines       Date:  2022-07-25

6.  Antiviral activity and possible mode of action of ellagic acid identified in Lagerstroemia speciosa leaves toward human rhinoviruses.

Authors:  Sang Wook Park; Min Jung Kwon; Ji Young Yoo; Hwa-Jung Choi; Young-Joon Ahn
Journal:  BMC Complement Altern Med       Date:  2014-05-26       Impact factor: 3.659

7.  Antiviral activity and possible mechanism of action of constituents identified in Paeonia lactiflora root toward human rhinoviruses.

Authors:  Luong Thi My Ngan; Myeong Jin Jang; Min Jung Kwon; Young Joon Ahn
Journal:  PLoS One       Date:  2015-04-10       Impact factor: 3.752

8.  Ferulic acid and PDMS modified medical carbon materials for artificial joint prosthesis.

Authors:  Xianlei Gao; Songgang Wang; Yeyang Xu; Hao Li; Hua Zhao; Xin Pan
Journal:  PLoS One       Date:  2018-09-05       Impact factor: 3.240

Review 9.  The human rhinovirus: human-pathological impact, mechanisms of antirhinoviral agents, and strategies for their discovery.

Authors:  Judith M Rollinger; Michaela Schmidtke
Journal:  Med Res Rev       Date:  2011-01       Impact factor: 12.944
  9 in total

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