Literature DB >> 18590684

Fine tuning of hepcidin expression by positive and negative regulators.

Martina U Muckenthaler1.   

Abstract

Hepcidin, the systemic regulator of iron homeostasis is activated by proteins responsible for hereditary hemochromatosis, bone morphogenetic proteins (BMPs), and inflammatory cytokines. Three recent publications now identify a novel hepcidin suppressor, the transmembrane serine protease TMPRSS6 (also known as matriptase-2), which is required to sense iron deficiency.

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Year:  2008        PMID： 18590684     DOI： 10.1016/j.cmet.2008.06.009

Source DB:  PubMed          Journal:  Cell Metab        ISSN： 1550-4131            Impact factor:   27.287


  34 in total

Review 1.  Targeting the hepcidin-ferroportin axis to develop new treatment strategies for anemia of chronic disease and anemia of inflammation.

Authors:  Chia Chi Sun; Valentina Vaja; Jodie L Babitt; Herbert Y Lin
Journal:  Am J Hematol       Date:  2012-01-31       Impact factor: 10.047

2.  Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.

Authors:  Irene Pichler; Cosetta Minelli; Serena Sanna; Toshiko Tanaka; Christine Schwienbacher; Silvia Naitza; Eleonora Porcu; Cristian Pattaro; Fabio Busonero; Alessandra Zanon; Andrea Maschio; Scott A Melville; Maria Grazia Piras; Dan L Longo; Jack Guralnik; Dena Hernandez; Stefania Bandinelli; Elmar Aigner; Anthony T Murphy; Victor Wroblewski; Fabio Marroni; Igor Theurl; Carsten Gnewuch; Eric Schadt; Manfred Mitterer; David Schlessinger; Luigi Ferrucci; Derrick R Witcher; Andrew A Hicks; Günter Weiss; Manuela Uda; Peter P Pramstaller
Journal:  Hum Mol Genet       Date:  2010-12-28       Impact factor: 6.150

Review 3.  Iron and the immune system.

Authors:  Roberta J Ward; Robert R Crichton; Deanna L Taylor; Laura Della Corte; Surjit K Srai; David T Dexter
Journal:  J Neural Transm (Vienna)       Date:  2010-09-29       Impact factor: 3.575

4.  Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs.

Authors:  Byung-Eun Kim; Michelle L Turski; Yasuhiro Nose; Michelle Casad; Howard A Rockman; Dennis J Thiele
Journal:  Cell Metab       Date:  2010-05-05       Impact factor: 27.287

5.  The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.

Authors:  Haarin Chun; Anuj Kumar Sharma; Jaekwon Lee; Jefferson Chan; Shang Jia; Byung-Eun Kim
Journal:  J Biol Chem       Date:  2016-11-23       Impact factor: 5.157

6.  Kinetics of iron removal by phlebotomy in patients with iron overload after allogeneic hematopoietic cell transplantation.

Authors:  Ann-Kathrin Eisfeld; Rainer Krahl; Nadja Jaekel; Dietger Niederwieser; Haifa Kathrin Al-Ali
Journal:  Am J Blood Res       Date:  2012-11-25

7.  Expression of hepcidin and other iron-related genes in type 3 hemochromatosis due to a novel mutation in transferrin receptor-2.

Authors:  Sara Pelucchi; Raffaella Mariani; Paola Trombini; Sabina Coletti; Matteo Pozzi; Valentina Paolini; Donatella Barisani; Alberto Piperno
Journal:  Haematologica       Date:  2009-01-14       Impact factor: 9.941

Review 8.  Role of matriptase-2 (TMPRSS6) in iron metabolism.

Authors:  Pauline Lee
Journal:  Acta Haematol       Date:  2009-11-10       Impact factor: 2.195

9.  A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA.

Authors:  Sandro Altamura; Flavia D'Alessio; Barbara Selle; Martina U Muckenthaler
Journal:  Biochem J       Date:  2010-11-01       Impact factor: 3.857

10.  A hepcidin lowering agent mobilizes iron for incorporation into red blood cells in an adenine-induced kidney disease model of anemia in rats.

Authors:  Chia Chi Sun; Valentina Vaja; Shanzhuo Chen; Igor Theurl; Aaron Stepanek; Diane E Brown; Maria D Cappellini; Guenter Weiss; Charles C Hong; Herbert Y Lin; Jodie L Babitt
Journal:  Nephrol Dial Transplant       Date:  2013-01-22       Impact factor: 5.992
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