INTRODUCTION: To achieve a high graft survival rate, patient adherence to immunosuppressive therapy is critical. It is extremely difficult to establish the actual adherence status of transplant recipients; only a few surveys on the issue have been performed in Japan. METHODS: We conducted a questionnaire survey mainly on treatment adherence to calcineurin inhibitors among renal transplant recipients. RESULTS: The survey demonstrated some degree of nonadherence in a relatively high percentage of the patients. The adherence rate was significantly lower for the evening than the morning dose (McNemar test, P < .001). It significantly decreased with time following transplantation for both the morning and the evening doses (logistic regression analysis, P = .025 and <.001, respectively). CONCLUSIONS: Immunosuppressive treatment places a substantial burden on patients, some of whom cannot continue regular treatment at specified time points due to daily life restrictions after they have returned to work.
INTRODUCTION: To achieve a high graft survival rate, patient adherence to immunosuppressive therapy is critical. It is extremely difficult to establish the actual adherence status of transplant recipients; only a few surveys on the issue have been performed in Japan. METHODS: We conducted a questionnaire survey mainly on treatment adherence to calcineurin inhibitors among renal transplant recipients. RESULTS: The survey demonstrated some degree of nonadherence in a relatively high percentage of the patients. The adherence rate was significantly lower for the evening than the morning dose (McNemar test, P < .001). It significantly decreased with time following transplantation for both the morning and the evening doses (logistic regression analysis, P = .025 and <.001, respectively). CONCLUSIONS: Immunosuppressive treatment places a substantial burden on patients, some of whom cannot continue regular treatment at specified time points due to daily life restrictions after they have returned to work.
Authors: Bing Ho; Hardik Bhagat; Jason J Schwartz; Kofi Atiemo; Amna Daud; Raymond Kang; Samantha E Montag; Lihui Zhao; Edward Lee; Anton I Skaro; Daniela P Ladner Journal: Adv Ther Date: 2019-04-02 Impact factor: 3.845
Authors: Regina van Zanten; Annelies de Weerd; Michiel Betjes; Marieken Boer-Verschragen; Emma K Massey Journal: Transpl Int Date: 2021-09 Impact factor: 3.842
Authors: Gorden Muduma; Francis C Shupo; Sophie Dam; Natalia A Hawken; Samuel Aballéa; Isaac Odeyemi; Mondher Toumi Journal: Patient Prefer Adherence Date: 2016-01-12 Impact factor: 2.711