ETHNOPHARMACOLOGICAL RELEVANCE: The bee pollen is used in folk medicine to alleviate allergic reactions. The bee pollen phenolic extract (BPPE) consists in phenolic compounds (flavonoids) from plants picked by Apis mellifera bee. AIM OF THIS STUDY: Here we evaluated the anti-allergic property of the BPPE and the flavonoid myricetin (MYR) in murine model of ovalbumin (OVA)-induced allergy. MATERIALS AND METHODS: The study focused on the BPPE or myricetin treatment of OVA-sensitized BALB/c mice and their effects on the IgE and IgG1 production, pulmonary cell migration, eosinophil peroxidase (EPO) activity and anaphylactic shock reaction. RESULTS: The BPPE treatment (200mg/kg) showed inhibition of the paw edema, IgE and IgG(1) OVA-specific production, leukocyte migration to the bronchoalveolar lavage (BAL) and EPO activity in lungs. In addition, BPPE treatment showed partial protection on the anaphylactic shock reaction induced by OVA. Treatment with myricetin (5 mg/kg) also inhibited pulmonary cell migration and IgE and IgG(1) OVA-specific production. CONCLUSIONS: These results support the hypothesis the myricetin is one of the flavonoids of BPPE responsible for the anti-allergic effect and a potential tool to treat allergies.
ETHNOPHARMACOLOGICAL RELEVANCE: The bee pollen is used in folk medicine to alleviate allergic reactions. The bee pollen phenolic extract (BPPE) consists in phenolic compounds (flavonoids) from plants picked by Apis mellifera bee. AIM OF THIS STUDY: Here we evaluated the anti-allergic property of the BPPE and the flavonoid myricetin (MYR) in murine model of ovalbumin (OVA)-induced allergy. MATERIALS AND METHODS: The study focused on the BPPE or myricetin treatment of OVA-sensitized BALB/c mice and their effects on the IgE and IgG1 production, pulmonary cell migration, eosinophil peroxidase (EPO) activity and anaphylactic shock reaction. RESULTS: The BPPE treatment (200mg/kg) showed inhibition of the paw edema, IgE and IgG(1) OVA-specific production, leukocyte migration to the bronchoalveolar lavage (BAL) and EPO activity in lungs. In addition, BPPE treatment showed partial protection on the anaphylactic shock reaction induced by OVA. Treatment with myricetin (5 mg/kg) also inhibited pulmonary cell migration and IgE and IgG(1) OVA-specific production. CONCLUSIONS: These results support the hypothesis the myricetin is one of the flavonoids of BPPE responsible for the anti-allergic effect and a potential tool to treat allergies.
Authors: Jari S Algethami; Aida A Abd El-Wahed; Mohamed H Elashal; Hanan R Ahmed; Esraa H Elshafiey; Eslam M Omar; Yahya Al Naggar; Ahmed F Algethami; Qiyang Shou; Sultan M Alsharif; Baojun Xu; Awad A Shehata; Zhiming Guo; Shaden A M Khalifa; Kai Wang; Hesham R El-Seedi Journal: Nutrients Date: 2022-07-12 Impact factor: 6.706
Authors: Marta Santos Serafim Machado; Hugo Bernardino Ferreira Silva; Raimon Rios; Anaque Pires de Oliveira; Noma Vilany Queiroz Carneiro; Ryan Santos Costa; William Santos Alves; Fabio-Luis Meneses Souza; Eudes da Silva Velozo; Silvana Alves de Souza; Tania Maria Sarmento Silva; Maria Lenise Silva; Lain Carlos Pontes-de-Carvalho; Neuza Maria Alcântara-Neves; Camila Alexandrina Figueiredo Journal: BMC Complement Altern Med Date: 2015-06-06 Impact factor: 3.659
Authors: Shaden A M Khalifa; Mohamed H Elashal; Nermeen Yosri; Ming Du; Syed G Musharraf; Lutfun Nahar; Satyajit D Sarker; Zhiming Guo; Wei Cao; Xiaobo Zou; Aida A Abd El-Wahed; Jianbo Xiao; Hany A Omar; Mohamed-Elamir F Hegazy; Hesham R El-Seedi Journal: Nutrients Date: 2021-05-31 Impact factor: 5.717