Literature DB >> 18588945

Protein phosphatase 2A regulatory subunits and cancer.

Pieter J A Eichhorn1, Menno P Creyghton, René Bernards.   

Abstract

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an integral role in the regulation of a number of major signaling pathways whose deregulation can contribute to cancer. The specificity and activity of PP2A are highly regulated through the interaction of a family of regulatory B subunits with the substrates. Accumulating evidence indicates that PP2A acts as a tumor suppressor. In this review we summarize the known effects of specific PP2A holoenzymes and their roles in cancer relevant pathways. In particular we highlight PP2A function in the regulation of MAPK and Wnt signaling.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18588945     DOI： 10.1016/j.bbcan.2008.05.005

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  234 in total

1.  Misshapen-like kinase 1 (MINK1) is a novel component of striatin-interacting phosphatase and kinase (STRIPAK) and is required for the completion of cytokinesis.

Authors:  Toshinori Hyodo; Satoko Ito; Hitoki Hasegawa; Eri Asano; Masao Maeda; Takeshi Urano; Masahide Takahashi; Michinari Hamaguchi; Takeshi Senga
Journal:  J Biol Chem       Date:  2012-06-04       Impact factor: 5.157

2.  Protein phosphatase 2A negatively regulates eukaryotic initiation factor 4E phosphorylation and eIF4F assembly through direct dephosphorylation of Mnk and eIF4E.

Authors:  Yikun Li; Ping Yue; Xingming Deng; Takeshi Ueda; Rikiro Fukunaga; Fadlo R Khuri; Shi-Yong Sun
Journal:  Neoplasia       Date:  2010-10       Impact factor: 5.715

3.  HEAT repeat 1 motif is required for B56γ-containing protein phosphatase 2A (B56γ-PP2A) holoenzyme assembly and tumor-suppressive function.

Authors:  Yumiko Nobumori; Geoffrey P Shouse; Li Fan; Xuan Liu
Journal:  J Biol Chem       Date:  2012-02-07       Impact factor: 5.157

4.  DNAJB6 chaperones PP2A mediated dephosphorylation of GSK3β to downregulate β-catenin transcription target, osteopontin.

Authors:  A Mitra; M E Menezes; L K Pannell; M S Mulekar; R E Honkanen; L A Shevde; R S Samant
Journal:  Oncogene       Date:  2012-01-23       Impact factor: 9.867

Review 5.  Protein phosphatases and their regulation in the control of mitosis.

Authors:  Satoru Mochida; Tim Hunt
Journal:  EMBO Rep       Date:  2012-03       Impact factor: 8.807

6.  PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development.

Authors:  Zhigang Jin; Lindsay Wallace; Scott Q Harper; Jing Yang
Journal:  J Biol Chem       Date:  2010-08-31       Impact factor: 5.157

7.  The B56gamma3 regulatory subunit of protein phosphatase 2A (PP2A) regulates S phase-specific nuclear accumulation of PP2A and the G1 to S transition.

Authors:  Ting-Yuan Lee; Tai-Yu Lai; Shin-Chih Lin; Cheng-Wei Wu; In-Fan Ni; Yu-San Yang; Liang-Yi Hung; Brian K Law; Chi-Wu Chiang
Journal:  J Biol Chem       Date:  2010-05-06       Impact factor: 5.157

8.  Identification of PP2A complexes and pathways involved in cell transformation.

Authors:  Anna A Sablina; Melissa Hector; Nathalie Colpaert; William C Hahn
Journal:  Cancer Res       Date:  2010-12-15       Impact factor: 12.701

9.  Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function.

Authors:  Shaida Andrabi; Justin H Hwang; Jennifer Kean Choe; Thomas M Roberts; Brian S Schaffhausen
Journal:  J Virol       Date:  2011-08-10       Impact factor: 5.103

10.  Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1.

Authors:  H Liu; H Qiu; Y Song; Y Liu; H Wang; M Lu; M Deng; Y Gu; J Yin; K Luo; Z Zhang; X Jia; G Zheng; Z He
Journal:  Oncogene       Date:  2016-10-03       Impact factor: 9.867
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.