Literature DB >> 18588885

Specificity of the inhibitory effects of Dad on TGF-beta family type I receptors, Thickveins, Saxophone, and Baboon in Drosophila.

Yuto Kamiya1, Kohei Miyazono, Keiji Miyazawa.   

Abstract

In mammals, two inhibitory Smads (I-Smads), Smad6 and Smad7, play pivotal roles in negative regulation of TGF-beta family signaling. Smad7 ubiquitously inhibits TGF-beta family signaling, whereas Smad6 inhibits signaling from the ALK-3/6 subfamily in preference to that from the ALK-1/2 and ALK-4/5/7 subfamilies of TGF-beta family type I receptors. In Drosophila, only one I-Smad, Dad, has been identified. Here we examined inhibitory effects of Dad on type I receptors in Drosophila. Dad inhibited Saxophone (ALK-1/2 orthologue) and Thickveins (ALK-3/6 orthologue) but not Baboon (ALK-4/5/7 orthologue). The differential modes of action of I-Smads in mammals and Drosophila are discussed.

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Year:  2008        PMID： 18588885     DOI： 10.1016/j.febslet.2008.05.052

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  14 in total

1.  Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction.

Authors:  Yuto Kamiya; Kohei Miyazono; Keiji Miyazawa
Journal:  J Biol Chem       Date:  2010-07-27       Impact factor: 5.157

Review 2.  Strategies for exploring TGF-β signaling in Drosophila.

Authors:  Aidan J Peterson; Michael B O'Connor
Journal:  Methods       Date:  2014-03-27       Impact factor: 3.608

Review 3.  Cease and desist: modulating short-range Dpp signalling in the stem-cell niche.

Authors:  Robin E Harris; Hilary L Ashe
Journal:  EMBO Rep       Date:  2011-05-06       Impact factor: 8.807

Review 4.  TGF-β Family Signaling in Drosophila.

Authors:  Ambuj Upadhyay; Lindsay Moss-Taylor; Myung-Jun Kim; Arpan C Ghosh; Michael B O'Connor
Journal:  Cold Spring Harb Perspect Biol       Date:  2017-09-01       Impact factor: 10.005

Review 5.  Regulation of BMP activity and range in Drosophila wing development.

Authors:  Laurel A Raftery; David M Umulis
Journal:  Curr Opin Cell Biol       Date:  2011-12-05       Impact factor: 8.382

6.  The novel Smad protein Expansion regulates the receptor tyrosine kinase pathway to control Drosophila tracheal tube size.

Authors:  Ekaterini Iordanou; Rachana R Chandran; Yonghua Yang; Mina Essak; Nicholas Blackstone; Lan Jiang
Journal:  Dev Biol       Date:  2014-06-25       Impact factor: 3.582

7.  Retrograde BMP signaling modulates rapid activity-dependent synaptic growth via presynaptic LIM kinase regulation of cofilin.

Authors:  Zachary D Piccioli; J Troy Littleton
Journal:  J Neurosci       Date:  2014-03-19       Impact factor: 6.167

8.  Plasticity of TGF-β signaling.

Authors:  Geraldine Cellière; Georgios Fengos; Marianne Hervé; Dagmar Iber
Journal:  BMC Syst Biol       Date:  2011-11-03

9.  Membrane targeting of inhibitory Smads through palmitoylation controls TGF-β/BMP signaling.

Authors:  Wenqing Li; Weini Li; Lihui Zou; Shanming Ji; Chaoyi Li; Kehui Liu; Guoqiang Zhang; Qinmiao Sun; Fei Xiao; Dahua Chen
Journal:  Proc Natl Acad Sci U S A       Date:  2017-11-27       Impact factor: 11.205

10.  Drosophila motor neuron retraction during metamorphosis is mediated by inputs from TGF-β/BMP signaling and orphan nuclear receptors.

Authors:  Ana Boulanger; Morgane Farge; Christophe Ramanoudjame; Kristi Wharton; Jean-Maurice Dura
Journal:  PLoS One       Date:  2012-07-05       Impact factor: 3.240
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