Jinju Kim1. 1. Department of Oriental Physiology, College of Pharmacy, Kyung Hee University, Seoul, Korea. shdwer@khu.ac.kr
Abstract
BACKGROUND: Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake. METHODS: To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 200 overweight/obese Koreans were genotyped for four CHRNA2 SNPs using an Affymetrix Array Chip. RESULTS: Of four SNPs, only one, rs2043063, was associated with overweight/obesity in the study population (co-dominant, p=0.049; dominant, p=0.027). Associations between the significant SNP and obesity-related clinical characteristics were observed, but these were not significant. CONCLUSIONS: The CHRNA2 rs2043063 SNP might be a risk factor for overweight/obesity in Koreans. Therefore, further studies are needed to investigate whether mutations or common polymorphisms of the CHRNA2 gene represent a risk factor for obesity.
BACKGROUND: Genes correlated with nicotine may be important in obesity because of the role of nicotine in food intake. METHODS: To determine if single nucleotide polymorphisms (SNPs) in the neuronal nicotinic acetylcholine receptor alpha2 subunit gene (CHRNA2) are associated with overweight/obesity, 156 non-obese and 200 overweight/obese Koreans were genotyped for four CHRNA2 SNPs using an Affymetrix Array Chip. RESULTS: Of four SNPs, only one, rs2043063, was associated with overweight/obesity in the study population (co-dominant, p=0.049; dominant, p=0.027). Associations between the significant SNP and obesity-related clinical characteristics were observed, but these were not significant. CONCLUSIONS: The CHRNA2rs2043063 SNP might be a risk factor for overweight/obesity in Koreans. Therefore, further studies are needed to investigate whether mutations or common polymorphisms of the CHRNA2 gene represent a risk factor for obesity.
Authors: Paul Whiteaker; Jennifer A Wilking; Robert W B Brown; Robert J Brennan; Allan C Collins; Jon M Lindstrom; Jim Boulter Journal: Acta Pharmacol Sin Date: 2009-06 Impact factor: 6.150
Authors: Shahrdad Lotfipour; Janet S Byun; Prescott Leach; Christie D Fowler; Niall P Murphy; Paul J Kenny; Thomas J Gould; Jim Boulter Journal: J Neurosci Date: 2013-05-01 Impact factor: 6.167