Literature DB >> 18588280

Discovery of 4-amino and 4-hydroxy-1-aroylindoles as potent tubulin polymerization inhibitors.

Jing-Ping Liou1, Zi-Yi Wu, Ching-Chuan Kuo, Chi-Yen Chang, Pei-Yi Lu, Chi-Ming Chen, Hsing-Pang Hsieh, Jang-Yang Chang.   

Abstract

1-Aroylindoline, 1-aroyl-1,2,3,4-tetrahydroquinoline, and 1-aroylindole derivatives were synthesized and evaluated for anticancer activity. The 4-amino and 4-hydroxy-1-aroylindoles 26 and 27 with IC 50 of 0.9 and 0.6 microM, respectively, exhibited antitubulin activity superior or comparable to that of colchicine and combretastatin A-4. They also showed antiproliferative activity with IC 50 of 0.3-5.4 nM in a set of human cancer cell lines.

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Year:  2008        PMID： 18588280     DOI： 10.1021/jm800150d

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  8 in total

1.  Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent.

Authors:  Mallinath B Hadimani; Matthew T Macdonough; Anjan Ghatak; Tracy E Strecker; Ramona Lopez; Madhavi Sriram; Benson L Nguyen; John J Hall; Raymond J Kessler; Anupama R Shirali; Li Liu; Charles M Garner; George R Pettit; Ernest Hamel; David J Chaplin; Ralph P Mason; Mary Lynn Trawick; Kevin G Pinney
Journal:  J Nat Prod       Date:  2013-09-09       Impact factor: 4.050

Review 2.  An overview of tubulin inhibitors that interact with the colchicine binding site.

Authors:  Yan Lu; Jianjun Chen; Min Xiao; Wei Li; Duane D Miller
Journal:  Pharm Res       Date:  2012-07-20       Impact factor: 4.200

3.  Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.

Authors:  Mei-Jung Lai; Han-Li Huang; Shiow-Lin Pan; Yi-Min Liu; Chieh-Yu Peng; Hsueh-Yun Lee; Teng-Kuang Yeh; Po-Hsien Huang; Che-Ming Teng; Ching-Shih Chen; Hsun-Yueh Chuang; Jing-Ping Liou
Journal:  J Med Chem       Date:  2012-04-05       Impact factor: 7.446

4.  A robust iron catalyst for the selective hydrogenation of substituted (iso)quinolones.

Authors:  Basudev Sahoo; Carsten Kreyenschulte; Giovanni Agostini; Henrik Lund; Stephan Bachmann; Michelangelo Scalone; Kathrin Junge; Matthias Beller
Journal:  Chem Sci       Date:  2018-09-06       Impact factor: 9.825

5.  BF3-OEt2 Catalyzed C3-Alkylation of Indole: Synthesis of Indolylsuccinimidesand Their Cytotoxicity Studies.

Authors:  Iqbal N Shaikh; Abdul Rahim; Shaikh Faazil; Syed Farooq Adil; Mohamed E Assal; Mohammad Rafe Hatshan
Journal:  Molecules       Date:  2021-04-11       Impact factor: 4.411

6.  Synthesis and fungicidal activity of pyrazole derivatives containing 1,2,3,4-tetrahydroquinoline.

Authors:  Peng Lei; Xuebo Zhang; Yan Xu; Gaofei Xu; Xili Liu; Xinling Yang; Xiaohe Zhang; Yun Ling
Journal:  Chem Cent J       Date:  2016-07-04       Impact factor: 4.215

7.  One-Pot Multicomponent Synthesis and Bioevaluation of Tetrahydroquinoline Derivatives as Potential Antioxidants, α-Amylase Enzyme Inhibitors, Anti-Cancerous and Anti-Inflammatory Agents.

Authors:  Samra Farooq; Aqsa Mazhar; Areej Ghouri; Naseem Ullah
Journal:  Molecules       Date:  2020-06-11       Impact factor: 4.411

8.  A General Catalyst Based on Cobalt Core-Shell Nanoparticles for the Hydrogenation of N-Heteroarenes Including Pyridines.

Authors:  Kathiravan Murugesan; Vishwas G Chandrashekhar; Carsten Kreyenschulte; Matthias Beller; Rajenahally V Jagadeesh
Journal:  Angew Chem Int Ed Engl       Date:  2020-08-17       Impact factor: 16.823
  8 in total

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