Literature DB >> 18587994

Viscous reduction of turbulent damage in animal cell culture.

M S Croughan1, E S Sayre, D I Wang.   

Abstract

Animal cells are exposed to turbulent fluid flow in many cell culture processes. If the turbulence in the flow is sufficiently strong, the cells will be damaged or killed by fluid-mechanical forces. Through an increase in viscosity, the turbulence can be damped and the hydro-dynamic damage can be reduced. In this article, new experimental results are presented which illustrate the protective effect of thickening agents. The results follow the prediction of a model based on Kolmogorov's theory of universal equilibrium in turbulent flow fields.

Entities:  

Year:  1989        PMID: 18587994     DOI: 10.1002/bit.260330710

Source DB:  PubMed          Journal:  Biotechnol Bioeng        ISSN: 0006-3592            Impact factor:   4.530


  13 in total

1.  Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers.

Authors:  D E Martens; E A Nollen; M Hardeveld; C A Velden-de Groot; C D Gooijer; E C Beuvery; J Tramper
Journal:  Cytotechnology       Date:  1997-01       Impact factor: 2.058

2.  Death rate in a small air-lift loop reactor of vero cells grown on solid microcarriers and in macroporous microcarriers.

Authors:  D E Martens; E A Nollen; M Hardeveld; C A van der Velden-de Groot; C D de Gooijer; E C Beuvery; J Tramper
Journal:  Cytotechnology       Date:  1996-01       Impact factor: 2.058

3.  Scale up aspects of sparged insect-cell bioreactors.

Authors:  J Tramper; J M Vlak; C D de Gooijer
Journal:  Cytotechnology       Date:  1996-01       Impact factor: 2.058

4.  A hollow sphere soft lithography approach for long-term hanging drop methods.

Authors:  Won Gu Lee; Daniel Ortmann; Matthew J Hancock; Hojae Bae; Ali Khademhosseini
Journal:  Tissue Eng Part C Methods       Date:  2010-04       Impact factor: 3.056

5.  Microfluidic culture of single human embryonic stem cell colonies.

Authors:  Luis Gerardo Villa-Diaz; Yu-suke Torisawa; Tomoyuki Uchida; Jun Ding; Naiara Correa Nogueira-de-Souza; Kathy Sue O'Shea; Shuichi Takayama; Gary Daniel Smith
Journal:  Lab Chip       Date:  2009-03-24       Impact factor: 6.799

6.  Equipment design considerations for large scale cell culture.

Authors:  David M Marks
Journal:  Cytotechnology       Date:  2003-05       Impact factor: 2.058

7.  The potential of hydrodynamic damage to animal cells of industrial relevance: current understanding.

Authors:  Weiwei Hu; Claudia Berdugo; Jeffrey J Chalmers
Journal:  Cytotechnology       Date:  2011-07-22       Impact factor: 2.058

Review 8.  Advances in cell culture: anchorage dependence.

Authors:  Otto-Wilhelm Merten
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2015-02-05       Impact factor: 6.237

9.  A novel membrane bioreactor for microbial growth.

Authors:  S Beeton; B J Bellhouse; C J Knowles; H R Millward; A M Nicholson; J R Wyatt
Journal:  Appl Microbiol Biotechnol       Date:  1994-02       Impact factor: 4.813

10.  Rotating-wall vessels, promising bioreactors for osteoblastic cell culture: comparison with other 3D conditions.

Authors:  C Granet; N Laroche; L Vico; C Alexandre; M H Lafage-Proust
Journal:  Med Biol Eng Comput       Date:  1998-07       Impact factor: 2.602

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