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Literature DB >> 18587537

Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients.

Delia Kurzwelly¹, Claudia A Müller, Agnieszka Korfel, Eckhard Thiel, Michael Linnebank, Michael Weller, Ulrich Herrlinger.

Abstract

Human leukocyte antigens (HLA) are involved in the regulation of immune response to infection and in malignant transformation. Several HLA alleles are associated with immunological or malignant diseases. The aim of the present study was to evaluate a potential association of HLA class I and II alleles with primary central nervous system lymphoma (PCNSL) in immunocompetent patients. We therefore analyzed particular HLA-A, HLA-B and HLA-DRB1 alleles in 82 PCNSL patients and compared the data to those in 327 population controls. No significant difference between these two groups was found using Pearson's chi(2) test. These data do not support the hypothesis that HLA alleles play a major role in the pathogenesis of PCNSL.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2008 PMID： 18587537 DOI： 10.1007/s11060-008-9630-5

Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130

13 in total

1. Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.

Authors: M Montesinos-Rongen; R Küppers; D Schlüter; T Spieker; D Van Roost; C Schaller; G Reifenberger; O D Wiestler; M Deckert-Schlüter
Journal: Am J Pathol Date: 1999-12 Impact factor: 4.307

2. Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population.

Authors: A Manns; B Hanchard; O S Morgan; R Wilks; B Cranston; J M Nam; M Blank; M Kuwayama; S Yashiki; T Fujiyoshi; W Blattner; S Sonoda
Journal: J Natl Cancer Inst Date: 1998-04-15 Impact factor: 13.506

Review 3. Biology and management of AIDS-associated primary CNS lymphomas.

Authors: P A Forsyth; L M DeAngelis
Journal: Hematol Oncol Clin North Am Date: 1996-10 Impact factor: 3.722

4. Human leukocyte antigens as genetic markers in colorectal carcinoma.

Authors: M A Chatzipetrou; K E Tarassi; M M Konstadoulakis; H E Pappas; K D Zafirellis; T E Athanassiades; S A Papadopoulos; D G Panousopoulos; B C Golematis; C A Papasteriades
Journal: Dis Colon Rectum Date: 1999-01 Impact factor: 4.585

5. Posttransplant primary CNS lymphoma.

Authors: T G Phan; B P O'Neill; P J Kurtin
Journal: Neuro Oncol Date: 2000-10 Impact factor: 12.300

6. Brain glioma and human leukocyte antigens (HLA)--is there an association.

Authors: H K Machulla; F Steinborn; A Schaaf; V Heidecke; N G Rainov
Journal: J Neurooncol Date: 2001-05 Impact factor: 4.130

7. Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma.

Authors: A Diepstra; M Niens; E Vellenga; G W van Imhoff; I M Nolte; M Schaapveld; G van der Steege; A van den Berg; R E Kibbelaar; G J te Meerman; S Poppema
Journal: Lancet Date: 2005 Jun 25-Jul 1 Impact factor: 79.321

8. Comparative analysis of the association of HLA-B*51 suballeles with Behçet's disease in patients of German and Turkish origin.

Authors: I Kötter; I Günaydin; N Stübiger; H Yazici; I Fresko; C C Zouboulis; Y Adler; I Steiert; B Kurz; D Wernet; B Braun; C A Müller
Journal: Tissue Antigens Date: 2001-09

Primary CNS lymphoma and HLA class I and II alleles in a German cohort of immunocompetent patients.

1. Primary central nervous system lymphomas are derived from germinal-center B cells and show a preferential usage of the V4-34 gene segment.

2. Human leukocyte antigen class II alleles associated with human T-cell lymphotropic virus type I infection and adult T-cell leukemia/lymphoma in a Black population.

Review 3. Biology and management of AIDS-associated primary CNS lymphomas.

4. Human leukocyte antigens as genetic markers in colorectal carcinoma.

5. Posttransplant primary CNS lymphoma.

6. Brain glioma and human leukocyte antigens (HLA)--is there an association.

7. Association with HLA class I in Epstein-Barr-virus-positive and with HLA class III in Epstein-Barr-virus-negative Hodgkin's lymphoma.

8. Comparative analysis of the association of HLA-B*51 suballeles with Behçet's disease in patients of German and Turkish origin.

9. Mycosis fungoides: HLA class II associations among Ashkenazi and non-Ashkenazi Jewish patients.

10. The methionine synthase polymorphism D919G alters susceptibility to primary central nervous system lymphoma.

1. Genetic variants of folate and methionine metabolism and PCNSL incidence in a German patient population.

Review 2. Advances in Pathobiology of Primary Central Nervous System Lymphoma.