BACKGROUND: We performed a systematic review and meta-analysis to compare treatment outcomes for human epidermal growth factor receptor (HER)-2-positive breast cancer patients receiving adjuvant chemotherapy with or without trastuzumab. METHODS: We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed-effects meta-analysis was used to combine data. RESULTS: Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed-effects analysis showed disease-free survival to be superior for trastuzumab-treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56-0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57-0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43-0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52-0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07-14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84-2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06-2.40) was also noted in patients receiving trastuzumab. CONCLUSIONS: The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER-2-positive breast cancer patients.
BACKGROUND: We performed a systematic review and meta-analysis to compare treatment outcomes for humanepidermal growth factor receptor (HER)-2-positive breast cancerpatients receiving adjuvant chemotherapy with or without trastuzumab. METHODS: We identified randomized clinical trials comparing adjuvant chemotherapy with or without trastuzumab in patients with resectable breast cancer. Fixed-effects meta-analysis was used to combine data. RESULTS: Five eligible trials were identified, reporting outcomes on 13,493 women. Fixed-effects analysis showed disease-free survival to be superior for trastuzumab-treated patients (risk ratio [RR], 0.62; 95% confidence interval [CI], 0.56-0.68). Superiority was also observed for patients receiving trastuzumab with respect to mortality (RR, 0.66; 95% CI, 0.57-0.77), locoregional recurrence (RR, 0.58; 95% CI, 0.43-0.77), and distant recurrence (RR, 0.60; 95% CI, 0.52-0.68). Patients receiving trastuzumab with chemotherapy had a higher risk for congestive heart failure (RR, 7.60; 95% CI, 4.07-14.18) and left ventricular ejection fraction decline (RR, 2.09; 95% CI, 1.84-2.37). A higher risk for central nervous system metastasis as the first recurrence event (RR, 1.60; 95% CI, 1.06-2.40) was also noted in patients receiving trastuzumab. CONCLUSIONS: The use of trastuzumab should be considered an integral part of the adjuvant therapy of HER-2-positive breast cancerpatients.
Authors: Leonardo Gomes da Fonseca; Debora de Melo Gagliato; Tiago K Takahashi; Milena Perez Mak; Romualdo Barroso-Sousa; Laura Testa; Vanessa Petry Helena; Romulo de Paula Costa; Paulo M Hoff; Max S Mano Journal: Breast Care (Basel) Date: 2014-04 Impact factor: 2.860
Authors: P Martín Martorell; B Bermejo de Las Heras; J A Pérez-Fidalgo; M Huerta Alvaro; M Martín; J Albanell; A Lluch Hernández Journal: Clin Transl Oncol Date: 2014-04-29 Impact factor: 3.405