| Literature DB >> 18586481 |
Mohsen Sabouri-Ghomi1, Yi Wu, Klaus Hahn, Gaudenz Danuser.
Abstract
Understanding the structural adaptation and signaling of adhesion sites in response to mechanical stimuli requires in situ characterization of the dynamic activation of a large number of adhesion components. Here, we review high-resolution live cell imaging approaches to measure forces, assembly, and interaction of adhesion components, and the activation of adhesion-mediated signals. We conclude by outlining computational multiplexing as a framework for the integration of these data into comprehensive models of adhesion signaling pathways.Mesh：
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Year: 2008 PMID： 18586481 PMCID： PMC2661108 DOI： 10.1016/j.ceb.2008.05.004
Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382