Literature DB >> 18586085

Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.

Stuart J Frank1, Serge Y Fuchs.   

Abstract

Growth hormone plays an important role in regulating numerous functions in vertebrates. Several pathways that negatively regulate the magnitude and duration of its signaling (including expression of tyrosine phosphatases, SOCS and PIAS proteins) are shared between signaling induced by growth hormone itself and by other cytokines. Here we overview downregulation of the growth hormone receptor as the most specific and potent mechanism of restricting cellular responses to growth hormone and analyze the role of several proteolytic systems and, specifically, ubiquitin-dependent pathways in this regulation.

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Year:  2008        PMID： 18586085      PMCID： PMC2760287          DOI： 10.1016/j.bbadis.2008.06.001

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  136 in total

Review 1.  Growth hormone binding protein 2001.

Authors:  G Baumann
Journal:  J Pediatr Endocrinol Metab       Date:  2001-04       Impact factor: 1.634

2.  The signal transduction of the growth hormone receptor is regulated by the ubiquitin/proteasome system and continues after endocytosis.

Authors:  C M Alves dos Santos; P van Kerkhof; G J Strous
Journal:  J Biol Chem       Date:  2001-01-10       Impact factor: 5.157

3.  Metalloprotease-mediated GH receptor proteolysis and GHBP shedding. Determination of extracellular domain stem region cleavage site.

Authors:  Xiangdong Wang; Kai He; Mary Gerhart; Yao Huang; Jing Jiang; Raymond J Paxton; Shaohua Yang; Chunxia Lu; Ram K Menon; Roy A Black; Gerhard Baumann; Stuart J Frank
Journal:  J Biol Chem       Date:  2002-10-25       Impact factor: 5.157

4.  Growth hormone (GH)-induced dimerization inhibits phorbol ester-stimulated GH receptor proteolysis.

Authors:  Y Zhang; R Guan; J Jiang; J J Kopchick; R A Black; G Baumann; S J Frank
Journal:  J Biol Chem       Date:  2001-04-17       Impact factor: 5.157

5.  Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking.

Authors:  P Burke; K Schooler; H S Wiley
Journal:  Mol Biol Cell       Date:  2001-06       Impact factor: 4.138

6.  Activation of growth hormone receptor delivers an antiapoptotic signal: evidence for a role of Akt in this pathway.

Authors:  J A Costoya; J Finidori; S Moutoussamy; R Seãris; J Devesa; V M Arce
Journal:  Endocrinology       Date:  1999-12       Impact factor: 4.736

7.  SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms.

Authors:  P A Ram; D J Waxman
Journal:  J Biol Chem       Date:  1999-12-10       Impact factor: 5.157

8.  Proteasomes are involved in the constitutive degradation of growth hormone receptors.

Authors:  K Takagi; Y Saito; J I Sawada
Journal:  Biol Pharm Bull       Date:  2001-07       Impact factor: 2.233

9.  Growth hormone receptor ubiquitination coincides with recruitment to clathrin-coated membrane domains.

Authors:  P van Kerkhof; M Sachse; J Klumperman; G J Strous
Journal:  J Biol Chem       Date:  2000-10-19       Impact factor: 5.157

10.  Phorbol ester- and growth factor-induced growth hormone (GH) receptor proteolysis and GH-binding protein shedding: relationship to GH receptor down-regulation.

Authors:  R Guan; Y Zhang; J Jiang; C A Baumann; R A Black; G Baumann; S J Frank
Journal:  Endocrinology       Date:  2001-03       Impact factor: 4.736
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  9 in total

Review 1.  Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.

Authors:  Christopher J Carbone; Serge Y Fuchs
Journal:  J Cell Biochem       Date:  2014-01       Impact factor: 4.429

Review 2.  Update on prognostic factors in acromegaly: Is a risk score possible?

Authors:  E Fernandez-Rodriguez; F F Casanueva; I Bernabeu
Journal:  Pituitary       Date:  2015-06       Impact factor: 4.107

3.  Signaling cross talk between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in pancreatic islet β-cells.

Authors:  Fanxin Ma; Zhe Wei; Chunwei Shi; Yan Gan; Jia Lu; Stuart J Frank; James Balducci; Yao Huang
Journal:  Mol Endocrinol       Date:  2011-10-27

4.  Dynamic analysis of GH receptor conformational changes by split luciferase complementation.

Authors:  Ying Liu; Philip A Berry; Yue Zhang; Jing Jiang; Peter E Lobie; Ramasamy Paulmurugan; John F Langenheim; Wen Y Chen; Kurt R Zinn; Stuart J Frank
Journal:  Mol Endocrinol       Date:  2014-09-04

5.  Growth hormone-induced JAK2 signaling and GH receptor down-regulation: role of GH receptor intracellular domain tyrosine residues.

Authors:  Luqin Deng; Jing Jiang; Stuart J Frank
Journal:  Endocrinology       Date:  2012-03-13       Impact factor: 4.736

Review 6.  Growth hormone - past, present and future.

Authors:  Michael B Ranke; Jan M Wit
Journal:  Nat Rev Endocrinol       Date:  2018-03-16       Impact factor: 43.330

7.  TIMP3 Modulates GHR Abundance and GH Sensitivity.

Authors:  Yue Zhang; Xiangdong Wang; Kimberly Loesch; Larry A May; George E Davis; Jing Jiang; Stuart J Frank
Journal:  Mol Endocrinol       Date:  2016-04-13

Review 8.  Endosomal transport via ubiquitination.

Authors:  Robert C Piper; Paul J Lehner
Journal:  Trends Cell Biol       Date:  2011-09-28       Impact factor: 20.808

Review 9.  Classical and novel GH receptor signaling pathways.

Authors:  Stuart J Frank
Journal:  Mol Cell Endocrinol       Date:  2020-08-22       Impact factor: 4.102
  9 in total

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