Literature DB >> 18585748

A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets.

Tomy Joseph1, Josephine McAuliffe, Bin Lu, Leatrice Vogel, David Swayne, Hong Jin, George Kemble, Kanta Subbarao.   

Abstract

The appearance of human infections caused by avian influenza A H7 subtype viruses underscores their pandemic potential and the need to develop vaccines to protect humans from viruses of this subtype. A live attenuated H7N3 virus vaccine was generated by reverse genetics using the HA and NA genes of a low pathogenicity A/chicken/BC/CN-6/04 (H7N3) virus and the six internal protein genes of the cold-adapted A/Ann Arbor/6/60 ca (H2N2) virus. The reassortant H7N3 BC 04 ca vaccine virus was temperature sensitive and showed attenuation in mice and ferrets. Intranasal immunization with one dose of the vaccine protected mice and ferrets when challenged with homologous and heterologous H7 viruses. The reassortant H7N3 BC 04 ca vaccine virus showed comparable levels of attenuation, immunogenicity and efficacy in mice and ferret models. The safety, immunogenicity, and efficacy of this vaccine in mice and ferrets support the evaluation of this vaccine in clinical trials.

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Year:  2008        PMID： 18585748      PMCID： PMC2586151          DOI： 10.1016/j.virol.2008.05.021

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  30 in total

Review 1.  Principles underlying the development and use of live attenuated cold-adapted influenza A and B virus vaccines.

Authors:  Brian R Murphy; Kathleen Coelingh
Journal:  Viral Immunol       Date:  2002       Impact factor: 2.257

2.  H7N3 avian influenza in Italy.

Authors:  Ilaria Capua; Stefano Marangon; Paolo Cordioli; Lebana Bonfanti; Ugo Santucci
Journal:  Vet Rec       Date:  2002-12-14       Impact factor: 2.695

3.  Intersegmental recombination between the haemagglutinin and matrix genes was responsible for the emergence of a highly pathogenic H7N3 avian influenza virus in British Columbia.

Authors:  John Pasick; Katherine Handel; John Robinson; John Copps; Deidre Ridd; Kevin Hills; Helen Kehler; Colleen Cottam-Birt; James Neufeld; Yohannes Berhane; Stefanie Czub
Journal:  J Gen Virol       Date:  2005-03       Impact factor: 3.891

4.  A DNA transfection system for generation of influenza A virus from eight plasmids.

Authors:  E Hoffmann; G Neumann; Y Kawaoka; G Hobom; R G Webster
Journal:  Proc Natl Acad Sci U S A       Date:  2000-05-23       Impact factor: 11.205

5.  Multiple amino acid residues confer temperature sensitivity to human influenza virus vaccine strains (FluMist) derived from cold-adapted A/Ann Arbor/6/60.

Authors:  Hong Jin; Bin Lu; Helen Zhou; Chienhui Ma; Jackie Zhao; Chin-fen Yang; George Kemble; Harry Greenberg
Journal:  Virology       Date:  2003-02-01       Impact factor: 3.616

Review 6.  The development of live attenuated cold-adapted influenza virus vaccine for humans.

Authors:  H F Maassab; M L Bryant
Journal:  Rev Med Virol       Date:  1999 Oct-Dec       Impact factor: 6.989

7.  Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain.

Authors:  Emmie de Wit; Vincent J Munster; Monique I J Spronken; Theo M Bestebroer; Chantal Baas; Walter E P Beyer; Guus F Rimmelzwaan; Albert D M E Osterhaus; Ron A M Fouchier
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

8.  Generation and characterization of a cold-adapted influenza A H9N2 reassortant as a live pandemic influenza virus vaccine candidate.

Authors:  H Chen; Y Matsuoka; David Swayne; Q Chen; N J Cox; B R Murphy; K Subbarao
Journal:  Vaccine       Date:  2003-10-01       Impact factor: 3.641

9.  Infection due to 3 avian influenza subtypes in United States veterinarians.

Authors:  Kendall P Myers; Sharon F Setterquist; Ana W Capuano; Gregory C Gray
Journal:  Clin Infect Dis       Date:  2007-05-24       Impact factor: 9.079

10.  Molecular analysis of avian H7 influenza viruses circulating in Eurasia in 1999-2005: detection of multiple reassortant virus genotypes.

Authors:  Laura Campitelli; Angela Di Martino; Domenico Spagnolo; Gavin J D Smith; Livia Di Trani; Marzia Facchini; Maria Alessandra De Marco; Emanuela Foni; Chiara Chiapponi; Ana Moreno Martin; Honglin Chen; Yi Guan; Mauro Delogu; Isabella Donatelli
Journal:  J Gen Virol       Date:  2008-01       Impact factor: 3.891
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  47 in total

1.  Classical swine H1N1 influenza viruses confer cross protection from swine-origin 2009 pandemic H1N1 influenza virus infection in mice and ferrets.

Authors:  Ji-Young Min; Grace L Chen; Celia Santos; Elaine W Lamirande; Yumiko Matsuoka; Kanta Subbarao
Journal:  Virology       Date:  2010-12-05       Impact factor: 3.616

2.  An adjuvant for the induction of potent, protective humoral responses to an H5N1 influenza virus vaccine with antigen-sparing effect in mice.

Authors:  Yuk-Fai Lau; Lay-Hoon Tang; Amber W McCall; Eng-Eong Ooi; Kanta Subbarao
Journal:  J Virol       Date:  2010-06-10       Impact factor: 5.103

Review 3.  Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target.

Authors:  Neetu Singh; Aseem Pandey; Suresh K Mittal
Journal:  Expert Rev Mol Med       Date:  2010-04-29       Impact factor: 5.600

4.  The magnitude of local immunity in the lungs of mice induced by live attenuated influenza vaccines is determined by local viral replication and induction of cytokines.

Authors:  Yuk-Fai Lau; Celia Santos; Fernando J Torres-Vélez; Kanta Subbarao
Journal:  J Virol       Date:  2010-10-20       Impact factor: 5.103

5.  Comparison of a live attenuated 2009 H1N1 vaccine with seasonal influenza vaccines against 2009 pandemic H1N1 virus infection in mice and ferrets.

Authors:  Grace L Chen; Ji-Young Min; Elaine W Lamirande; Celia Santos; Hong Jin; George Kemble; Kanta Subbarao
Journal:  J Infect Dis       Date:  2011-01-21       Impact factor: 5.226

Review 6.  Extending the Breadth of Influenza Vaccines: Status and Prospects for a Universal Vaccine.

Authors:  Annette Fox; Kylie M Quinn; Kanta Subbarao
Journal:  Drugs       Date:  2018-09       Impact factor: 9.546

7.  African green monkeys recapitulate the clinical experience with replication of live attenuated pandemic influenza virus vaccine candidates.

Authors:  Yumiko Matsuoka; Amorsolo Suguitan; Marlene Orandle; Myeisha Paskel; Kobporn Boonnak; Donald J Gardner; Friederike Feldmann; Heinz Feldmann; Michael Marino; Hong Jin; George Kemble; Kanta Subbarao
Journal:  J Virol       Date:  2014-05-07       Impact factor: 5.103

8.  Pathogenesis, transmissibility, and ocular tropism of a highly pathogenic avian influenza A (H7N3) virus associated with human conjunctivitis.

Authors:  Jessica A Belser; C Todd Davis; Amanda Balish; Lindsay E Edwards; Hui Zeng; Taronna R Maines; Kortney M Gustin; Irma López Martínez; Rodrigo Fasce; Nancy J Cox; Jacqueline M Katz; Terrence M Tumpey
Journal:  J Virol       Date:  2013-03-13       Impact factor: 5.103

Review 9.  Past, present, and possible future human infection with influenza virus A subtype H7.

Authors:  Jessica A Belser; Carolyn B Bridges; Jacqueline M Katz; Terrence M Tumpey
Journal:  Emerg Infect Dis       Date:  2009-06       Impact factor: 6.883

Review 10.  Current status of live attenuated influenza vaccine in the United States for seasonal and pandemic influenza.

Authors:  Christopher S Ambrose; Catherine Luke; Kathleen Coelingh
Journal:  Influenza Other Respir Viruses       Date:  2008-11       Impact factor: 4.380
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