OBJECTIVE: To report a case where intra-amniotic injection of methotrexate (MTX) was used to terminate a cervical ectopic pregnancy that was resistant to IM MTX treatment. DESIGN: Case report. PATIENT(S): A 31-year-old woman, gravida 2, para 1, presented with painless vaginal bleeding. An early cervical pregnancy was diagnosed by transvaginal ultrasound. INTERVENTION(S): Intramuscular MTX therapy was started without success, and an intra-amniotic injection of MTX under ultrasonographic guidance was performed. MAIN OUTCOME MEASURE(S): Pregnancy termination. RESULT(S): Pregnancy termination was successful, without complications or side effects. CONCLUSION(S): Local installation of MTX appears to be an effective and safe method; however, choice depends on gestational age, desire to preserve fertility, and, most of all, hemodynamic stability.
OBJECTIVE: To report a case where intra-amniotic injection of methotrexate (MTX) was used to terminate a cervical ectopic pregnancy that was resistant to IM MTX treatment. DESIGN: Case report. PATIENT(S): A 31-year-old woman, gravida 2, para 1, presented with painless vaginal bleeding. An early cervical pregnancy was diagnosed by transvaginal ultrasound. INTERVENTION(S): Intramuscular MTX therapy was started without success, and an intra-amniotic injection of MTX under ultrasonographic guidance was performed. MAIN OUTCOME MEASURE(S): Pregnancy termination. RESULT(S): Pregnancy termination was successful, without complications or side effects. CONCLUSION(S): Local installation of MTX appears to be an effective and safe method; however, choice depends on gestational age, desire to preserve fertility, and, most of all, hemodynamic stability.
Authors: P Giampaolino; N De Rosa; I Morra; A Bertrando; A Di Spiezio Sardo; B Zizolfi; C Ferrara; L Della Corte; G Bifulco Journal: Biomed Res Int Date: 2018-03-05 Impact factor: 3.411