BACKGROUND: Heart failure (HF) is one of the leading causes of morbidity and mortality among Americans. Despite increased interest in end-of-life care, the implications of do-not-resuscitate (DNR) orders in acutely ill patients with HF remain unclear. The goals of this observational study were to describe the use of DNR orders and their impact on treatment approaches in residents of a large New England metropolitan area hospitalized with acute heart failure. METHODS: Use of HF performance measures, including assessment of left ventricular function, use of angiotensin receptor blocking agents, anticoagulation, smoking cessation counseling, and use of nonpharmacologic strategies, was examined through review of the medical records of 4,537 metropolitan Worcester (MA) residents admitted to 11 central Massachusetts hospitals with acute HF in 1995 and 2000 according to the presence of DNR orders. RESULTS: Patients with DNR orders were less likely to have had their left ventricular function assessed (31% vs 43%) as well as receive renin-angiotensin system blockade (49% vs 57%), anticoagulation (65% vs 78%), or nonpharmacologic interventions (87% vs 92%) as compared to patients without DNR orders. Patients with DNR orders were significantly less likely to have received any quality assurance measure for acute HF (adjusted hazard ratio 0.63, 95% confidence interval 0.40-0.99) than patients without DNR orders. CONCLUSIONS: The use of quality assurance measures in acute HF is markedly lower in patients with DNR orders. The implications of DNR orders need to be further clarified in the treatment of patients with acute HF.
BACKGROUND:Heart failure (HF) is one of the leading causes of morbidity and mortality among Americans. Despite increased interest in end-of-life care, the implications of do-not-resuscitate (DNR) orders in acutely ill patients with HF remain unclear. The goals of this observational study were to describe the use of DNR orders and their impact on treatment approaches in residents of a large New England metropolitan area hospitalized with acute heart failure. METHODS: Use of HF performance measures, including assessment of left ventricular function, use of angiotensin receptor blocking agents, anticoagulation, smoking cessation counseling, and use of nonpharmacologic strategies, was examined through review of the medical records of 4,537 metropolitan Worcester (MA) residents admitted to 11 central Massachusetts hospitals with acute HF in 1995 and 2000 according to the presence of DNR orders. RESULTS:Patients with DNR orders were less likely to have had their left ventricular function assessed (31% vs 43%) as well as receive renin-angiotensin system blockade (49% vs 57%), anticoagulation (65% vs 78%), or nonpharmacologic interventions (87% vs 92%) as compared to patients without DNR orders. Patients with DNR orders were significantly less likely to have received any quality assurance measure for acute HF (adjusted hazard ratio 0.63, 95% confidence interval 0.40-0.99) than patients without DNR orders. CONCLUSIONS: The use of quality assurance measures in acute HF is markedly lower in patients with DNR orders. The implications of DNR orders need to be further clarified in the treatment of patients with acute HF.
Authors: Elizabeth A Jackson; Jorge L Yarzebski; Robert J Goldberg; Brownell Wheeler; Jerry H Gurwitz; Darleen M Lessard; Susanna E Bedell; Joel M Gore Journal: Arch Intern Med Date: 2004-04-12
Authors: Sandesh Dev; Robert M Clare; G Michael Felker; Mona Fiuzat; Lynne Warner Stevenson; Christopher M O'Connor Journal: Eur J Heart Fail Date: 2011-10-27 Impact factor: 15.534
Authors: Lior Fuchs; Matthew Anstey; Mengling Feng; Ronen Toledano; Slava Kogan; Michael D Howell; Peter Clardy; Leo Celi; Daniel Talmor; Victor Novack Journal: Crit Care Med Date: 2017-06 Impact factor: 7.598
Authors: Sydney E Dishman; Kathryn E Driggers; Laura S Johnson; Cara H Olsen; Andrea B Ryan; Melissa M McLawhorn; Kevin K Chung Journal: Crit Care Explor Date: 2020-07-16
Authors: Jane S Saczynski; Ezra Gabbay; David D McManus; Richard McManus; Joel M Gore; Jerry H Gurwitz; Darleen Lessard; Robert J Goldberg Journal: Clin Epidemiol Date: 2012-10-19 Impact factor: 4.790
Authors: Zoë Fritz; Alexandra Malyon; Jude M Frankau; Richard A Parker; Simon Cohn; Clare M Laroche; Chris R Palmer; Jonathan P Fuld Journal: PLoS One Date: 2013-09-04 Impact factor: 3.240
Authors: Yen-Yuan Chen; Nahida H Gordon; Alfred F Connors; Allan Garland; Shan-Chwen Chang; Stuart J Youngner Journal: BMC Med Date: 2014-08-29 Impact factor: 8.775