| Literature DB >> 18584353 |
M A Mayoral1, C Mayoral, A Meneses, L Villalvazo, A Guzman, B Espinosa, J L Ochoa, E Zenteno, J Guevara.
Abstract
Galectin-3 has been implicated in tumor progression. We demonstrated immunohistochemically that galectin-3 was negative in normal breast tissue, but it was highly increased in breast cancer and in metastatic tissues to brain. Similarly, histochemistry with mucin-specific lectins showed increased recognition in breast tumor and metastasis with Machaerocereus eruca agglutinin (Fualpha 1,2 (GalNAcalpha 1,3) Galss1,4 in complex mucin) but not for Amaranthus leucocarpus (Galss1,3-GalNAc-alpha 1,0-Ser/Thr) and Arachis hypogaea lectins (Galss1,3GalNAc/Galss1,4GlcNAc). Mucin-type glycans and galectin-3 colocalized in breast cancer and metastasis, but not in normal tissue, suggesting upregulated biosynthesis of complex O-glycosidically linked glycans and galectin-3 favor breast cancer progression and brain metastasis.Entities:
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Year: 2008 PMID： 18584353 DOI： 10.1080/07357900701837051
Source DB: PubMed Journal: Cancer Invest ISSN： 0735-7907 Impact factor: 2.176