Literature DB >> 18584348

Histone H3 (lys-9) deacetylation is associated with transcriptional silencing of E-cadherin in colorectal cancer cell lines.

Yanqun Liu1, Yi Hong, Yi Zhao, Tuty M Ismail, Yuhui Wong, Kong Weng Eu.   

Abstract

Epigenetic parameters linked to E-cadherin gene were investigated in 5 human colorectal cancer cell lines. Treatment with trichostatin A led to enhanced acetylation of histone H3-K9 with concurrent induction of E-cadherin mRNA in 3 E-cadherin low/negative cell lines that are not DNA methylated. Co-treatment with 5-aza-2'-deoxycytidine and trichostatin A resulted in additive/synergic induction of E-cadherin mRNA in all 5 cell lines with concomitant enhancement of histone H3-K9 acetylation in 4 E-cadherin low/negative cell lines. Our results suggest that histone H3-K9 deacetylation appears to play a crucial role in transcriptional repression of E-cadherin in colorectal cancers.

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Year:  2008        PMID： 18584348     DOI： 10.1080/07357900701837168

Source DB:  PubMed          Journal:  Cancer Invest        ISSN： 0735-7907            Impact factor:   2.176


  8 in total

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4.  E-cadherin promoter hypermethylation may contribute to protein inactivation in pterygia.

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Authors:  Shahper N Khan; Mohd Danishuddin; Bhavna Varshney; Sunil K Lal; Asad U Khan
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7.  Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles.

Authors:  Jenny A Watson; Declan J McKenna; Perry Maxwell; James Diamond; Ken Arthur; Valerie J McKelvey-Martin; Peter W Hamilton
Journal:  J Cell Mol Med       Date:  2009-07-06       Impact factor: 5.310

Review 8.  Role of Epigenetics in Biology and Human Diseases.

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Journal:  Iran Biomed J       Date:  2016-07-05
  8 in total

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