| Literature DB >> 18582952 |
M V Jones1, T T Nguyen, C A Deboy, J W Griffin, K A Whartenby, D A Kerr, P A Calabresi.
Abstract
We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments for multiple sclerosis (MS).Entities:
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Year: 2008 PMID： 18582952 DOI： 10.1016/j.jneuroim.2008.05.013
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478