Literature DB >> 18582198

Nevirapine resistance in women and infants after first versus repeated use of single-dose nevirapine for prevention of HIV-1 vertical transmission.

Tamara S Flys1, Michelle S McConnell, Flavia Matovu, Jessica D Church, Danstan Bagenda, Leila Khaki, Paul Bakaki, Michael C Thigpen, Chineta Eure, Mary Glenn Fowler, Susan H Eshleman.   

Abstract

Single-dose (SD) nevirapine (NVP) significantly reduces mother-to-child transmission of human immunodeficiency virus (HIV). We analyzed NVP resistance after receipt of SD NVP in 57 previously SD NVP-naive women, in 34 SD NVP-experienced women, and in 17 HIV-infected infants. The proportion of women infected with variants with resistance mutations, the types of mutations detected, and the frequency and level of K103N were similar in the two groups of women at 6 weeks and 6 months post partum. NVP resistance was detected in a similar proportion of infants born to SD NVP-naive versus SD NVP-experienced women. Repeated use of SD NVP to prevent HIV transmission does not appear to influence NVP resistance.

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Year:  2008        PMID： 18582198      PMCID： PMC2640946          DOI： 10.1086/590160

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

1.  Response to antiretroviral therapy after a single, peripartum dose of nevirapine.

Authors:  Shahin Lockman; Roger L Shapiro; Laura M Smeaton; Carolyn Wester; Ibou Thior; Lisa Stevens; Fatima Chand; Joseph Makhema; Claire Moffat; Aida Asmelash; Patrick Ndase; Peter Arimi; Erik van Widenfelt; Loeto Mazhani; Vladimir Novitsky; Stephen Lagakos; Max Essex
Journal:  N Engl J Med       Date:  2007-01-11       Impact factor: 91.245

2.  Persistence of nevirapine-resistant HIV-1 in women after single-dose nevirapine therapy for prevention of maternal-to-fetal HIV-1 transmission.

Authors:  S Palmer; V Boltz; N Martinson; F Maldarelli; G Gray; J McIntyre; J Mellors; L Morris; J Coffin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-25       Impact factor: 11.205

3.  Quantitative analysis of HIV-1 variants with the K103N resistance mutation after single-dose nevirapine in women with HIV-1 subtypes A, C, and D.

Authors:  Tamara S Flys; Shu Chen; Dana C Jones; Donald R Hoover; Jessica D Church; Susan A Fiscus; Anthony Mwatha; Laura A Guay; Francis Mmiro; Philippa Musoke; Newton Kumwenda; Taha E Taha; J Brooks Jackson; Susan H Eshleman
Journal:  J Acquir Immune Defic Syndr       Date:  2006-08-15       Impact factor: 3.731

4.  Transmission rates in consecutive pregnancies exposed to single-dose nevirapine in Soweto, South Africa and Abidjan, Côte d'Ivoire.

Authors:  Neil A Martinson; Didier K Ekouevi; Francois Dabis; Lynn Morris; Pumla Lupodwana; Besigin Tonwe-Gold; Puleng Dhlamini; Renaud Becquet; Jan G Steyn; Valériane Leroy; Ida Viho; Glenda E Gray; James A McIntyre
Journal:  J Acquir Immune Defic Syndr       Date:  2007-06-01       Impact factor: 3.731

5.  Persistence of K103N-containing HIV-1 variants after single-dose nevirapine for prevention of HIV-1 mother-to-child transmission.

Authors:  Tamara S Flys; Deborah Donnell; Anthony Mwatha; Clemensia Nakabiito; Philippa Musoke; Francis Mmiro; J Brooks Jackson; Laura A Guay; Susan H Eshleman
Journal:  J Infect Dis       Date:  2007-01-18       Impact factor: 5.226

6.  Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012.

Authors:  Tamara Flys; Dwight V Nissley; Cassidy W Claasen; Dana Jones; Chanjuan Shi; Laura A Guay; Philippa Musoke; Francis Mmiro; Jeffrey N Strathern; J Brooks Jackson; James R Eshleman; Susan H Eshleman
Journal:  J Infect Dis       Date:  2005-06-01       Impact factor: 5.226

7.  Emergence of drug-resistant HIV-1 after intrapartum administration of single-dose nevirapine is substantially underestimated.

Authors:  Jeffrey A Johnson; Jin-Fen Li; Lynn Morris; Neil Martinson; Glenda Gray; James McIntyre; Walid Heneine
Journal:  J Infect Dis       Date:  2005-06-01       Impact factor: 5.226

8.  Intrapartum exposure to nevirapine and subsequent maternal responses to nevirapine-based antiretroviral therapy.

Authors:  Gonzague Jourdain; Nicole Ngo-Giang-Huong; Sophie Le Coeur; Chureeratana Bowonwatanuwong; Pacharee Kantipong; Pranee Leechanachai; Surabhon Ariyadej; Prattana Leenasirimakul; Scott Hammer; Marc Lallemant
Journal:  N Engl J Med       Date:  2004-07-09       Impact factor: 91.245

9.  Early clinical and immune response to NNRTI-based antiretroviral therapy among women with prior exposure to single-dose nevirapine.

Authors:  Benjamin H Chi; Moses Sinkala; Elizabeth M Stringer; Ronald A Cantrell; Velepi Mtonga; Marc Bulterys; Isaac Zulu; Chipepo Kankasa; Catherine Wilfert; Paul J Weidle; Sten H Vermund; Jeffrey S A Stringer
Journal:  AIDS       Date:  2007-05-11       Impact factor: 4.177

10.  Detection of K103N in Ugandan women after repeated exposure to single dose nevirapine.

Authors:  Tamara S Flys; Anthony Mwatha; Laura A Guay; Clemensia Nakabiito; Deborah Donnell; Philippa Musoke; Francis Mmiro; J Brooks Jackson; Susan H Eshleman
Journal:  AIDS       Date:  2007-10-01       Impact factor: 4.177
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  7 in total

1.  HIV-1 drug resistance at antiretroviral treatment initiation in children previously exposed to single-dose nevirapine.

Authors:  Gillian M Hunt; Ashraf Coovadia; Elaine J Abrams; Gayle Sherman; Tammy Meyers; Lynn Morris; Louise Kuhn
Journal:  AIDS       Date:  2011-07-31       Impact factor: 4.177

2.  Estimating frequencies of minority nevirapine-resistant strains in chronically HIV-1-infected individuals naive to nevirapine by using stochastic simulations and a mathematical model.

Authors:  Saikrishna Gadhamsetty; Narendra M Dixit
Journal:  J Virol       Date:  2010-07-28       Impact factor: 5.103

3.  Maraviroc Population Pharmacokinetics Within the First 6 Weeks of Life.

Authors:  Marlon Liyanage; Mina Nikanjam; Lynn McFadyen; Manoli Vourvahis; Luise Rogg; John Moye; Ellen G Chadwick; Patrick Jean-Philippe; Mark Mirochnick; Kyle Whitson; Sarah Bradford; Edmund V Capparelli; Brookie M Best
Journal:  Pediatr Infect Dis J       Date:  2022-08-09       Impact factor: 3.806

4.  Clinical and Virologic Outcomes Following Initiation of Antiretroviral Therapy Among Seroconverters in the Microbicide Trials Network-020 Phase III Trial of the Dapivirine Vaginal Ring.

Authors:  Sharon A Riddler; Jennifer E Balkus; Urvi M Parikh; John W Mellors; Carolyne Akello; Sufia Dadabhai; Felix Mhlanga; Gita Ramjee; Ashley J Mayo; Edward Livant; Amy L Heaps; Colin O'Rourke; Jared M Baeten
Journal:  Clin Infect Dis       Date:  2019-07-18       Impact factor: 9.079

5.  In utero HIV infection is associated with an increased risk of nevirapine resistance in ugandan infants who were exposed to perinatal single dose nevirapine.

Authors:  Jessica D Church; Anthony Mwatha; Danstan Bagenda; Saad B Omer; Deborah Donnell; Philippa Musoke; Clemensia Nakabiito; Chineta Eure; Paul Bakaki; Flavia Matovu; Michael C Thigpen; Laura A Guay; Michelle McConnell; Mary Glenn Fowler; J Brooks Jackson; Susan H Eshleman
Journal:  AIDS Res Hum Retroviruses       Date:  2009-07       Impact factor: 2.205

6.  Prevalence and effect of pre-treatment drug resistance on the virological response to antiretroviral treatment initiated in HIV-infected children - a EuroCoord-CHAIN-EPPICC joint project.

Authors:  Nicole Ngo-Giang-Huong; Linda Wittkop; Ali Judd; Peter Reiss; Tessa Goetghebuer; Dan Duiculescu; Antoni Noguera-Julian; Magdalena Marczynska; Carlo Giacquinto; Luminita Ene; Jose T Ramos; Cristina Cellerai; Thomas Klimkait; Benedicte Brichard; Niels Valerius; Caroline Sabin; Ramon Teira; Niels Obel; Christoph Stephan; Stéphane de Wit; Claire Thorne; Diana Gibb; Christine Schwimmer; Maria Athena Campbell; Deenan Pillay; Marc Lallemant
Journal:  BMC Infect Dis       Date:  2016-11-08       Impact factor: 3.090

7.  Reuse of single-dose nevirapine in subsequent pregnancies for the prevention of mother-to-child HIV transmission in Lusaka, Zambia: a cohort study.

Authors:  Jan Walter; Louise Kuhn; Chipepo Kankasa; Katherine Semrau; Moses Sinkala; Donald M Thea; Grace M Aldrovandi
Journal:  BMC Infect Dis       Date:  2008-12-30       Impact factor: 3.090
  7 in total

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